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Review
. 2017 Nov;52(S48):S21-S28.
doi: 10.1002/ppul.23768. Epub 2017 Jul 17.

Mapping targetable inflammation and outcomes with cystic fibrosis biomarkers

Olivia Giddings  1   2   3 , Charles R Esther Jr  2   3
Affiliations
Review

Mapping targetable inflammation and outcomes with cystic fibrosis biomarkers

Olivia Giddings et al. Pediatr Pulmonol. 2017 Nov.

Abstract

Cystic fibrosis is characterized by an overly exuberant neutrophilic inflammatory response to pathogens and other stimuli that starts very early in disease. The overwhelming nature of this response is a primary cause of remodeling and destruction of the airways, suggesting that anti-inflammatory therapies could be beneficial in CF. However, finding therapies that can effectively reduce the inflammatory response without compromising host defenses remains elusive. New approaches towards mapping inflammatory targets promise to aid in developing novel therapeutic strategies and improve outcomes in individuals with CF.

Keywords: Sputum; bronchoalveolar lavage; exhaled breath condensate; metabolomics.

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Conflict of interest statement

Conflicts of Interest: none declared

Figures

Figure 1
Figure 1
Factors that contribute to the excessive inflammatory response in CF
Figure 2
Figure 2
Ease of collection and ease of biomarker measurement (including processing steps) are generally inversely related.
See this image and copyright information in PMC

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