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. 2017 Aug 7;56(33):9949-9952.
doi: 10.1002/anie.201704862. Epub 2017 Jul 17.

Nickel-Catalyzed Intermolecular Carbosulfonylation of Alkynes via Sulfonyl Radicals

Andrés García-Domínguez  1 , Simona Müller  1 , Cristina Nevado  1
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Nickel-Catalyzed Intermolecular Carbosulfonylation of Alkynes via Sulfonyl Radicals

Andrés García-Domínguez et al. Angew Chem Int Ed Engl. .

Abstract

β,β-Disubstituted vinyl sulfones were obtained with complete regio- and stereocontrol in a multicomponent reaction involving alkynes, organoboronic acids, and sulfonyl chlorides in the presence of a nickel catalyst. The reaction proceeds via sulfonyl radicals generated in situ under mild reaction conditions.

Keywords: carbosulfonylation; nickel; stereoselectivity; sulfonyl radicals; vinyl radicals.

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