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Comment
. 2017 Sep;42(9):682-684.
doi: 10.1016/j.tibs.2017.06.009. Epub 2017 Jul 14.

Shaping and Reshaping Transcriptome Plasticity during Evolution

Shobbir Hussain  1
Affiliations
Comment

Shaping and Reshaping Transcriptome Plasticity during Evolution

Shobbir Hussain. Trends Biochem Sci. 2017 Sep.

Abstract

Transcriptome plasticity, usually associated with alternative isoform generation, is recognised as a key mechanism driving proteomic diversity and biological complexity. Recent findings of Liscovitch-Brauer et al. and Ma et al. suggest that RNA base modifications are an additional central mode of transcriptome malleability that have the potential to determine evolutionary outcomes.

Keywords: A-I editing; RNA modifications; cephalopods; coleoids; epitranscriptome; inosine; m6A; organismal complexity.

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