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Review
. 2018 Jan:181:91-100.
doi: 10.1016/j.pharmthera.2017.07.005. Epub 2017 Jul 15.

Toxicity profiles of immunotherapy

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Review

Toxicity profiles of immunotherapy

S Cousin et al. Pharmacol Ther. 2018 Jan.

Abstract

Immunotherapies are changing the landscape of advanced solid tumor treatment. These therapies have different mechanisms of action and include oncolytic viruses, checkpoint inhibitors, such as CTLA-4 or PD1/PD-L1 monoclonal antibodies, and CSF-1R antibodies. Given the growing therapeutic impact of these agents in oncology, it is important to better understand their properties. Immunotherapies generate new toxicity profiles that are called immune-related adverse events and require specific management. This review focuses on the mechanisms of action of such side effects, as well as their description and their general management.

Keywords: Checkpoint inhibitors; Management; Mechanisms; Oncolytic viruses; irAEs.

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