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Review
. 2017 Jun;8(6-7):101-108.
doi: 10.1177/2040622317710010. Epub 2017 Jun 23.

Achalasia: current therapeutic options

Zubin Arora  1 , Prashanthi N Thota  1 , Madhusudhan R Sanaka  2
Affiliations
Review

Achalasia: current therapeutic options

Zubin Arora et al. Ther Adv Chronic Dis. 2017 Jun.

Abstract

Achalasia is a chronic incurable esophageal motility disorder characterized by impaired lower esophageal sphincter (LES) relaxation and loss of esophageal peristalsis. Although rare, it is currently the most common primary esophageal motility disorder, with an annual incidence of around 1.6 per 100,000 persons and prevalence of around 10.8/100,000 persons. Symptoms of achalasia include dysphagia to both solids and liquids, regurgitation, aspiration, chest pain and weight loss. As the underlying etiology of achalasia remains unclear, there is currently no curative treatment for achalasia. Management of achalasia mainly involves improving the esophageal outflow in order to provide symptomatic relief to patients. The most effective treatment options for achalasia include pneumatic dilation, Heller myotomy and peroral endoscopic myotomy (POEM), with the latter increasingly emerging as the treatment of choice for many patients. This review focusses on evidence for current and emerging treatment options for achalasia with a particular emphasis on POEM.

Keywords: Heller myotomy; achalasia; dysphagia; manometry; peroral endoscopic myotomy; pneumatic dilation.

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Conflict of interest statement

Conflict of interest statement: The authors declare that there is no conflict of interest.

References

    1. Krill JT, Naik RD, Vaezi MF. Clinical management of achalasia: current state of the art. Clin Exp Gastroenterol 2016; 9: 71–82. - PMC - PubMed
    1. Moonen A, Boeckxstaens G. Current diagnosis and management of achalasia. J Clin Gastroenterol 2014; 48: 484–490. - PubMed
    1. Sadowski DC, Ackah F, Jiang B, et al. Achalasia: incidence, prevalence and survival: a population-based study. Neurogastroenterol Motil 2010; 22: e256–e261. - PubMed
    1. Fisichella PM, Raz D, Palazzo F, et al. Clinical, radiological, and manometric profile in 145 patients with untreated achalasia. World J Surg 2008; 32: 1974–1979. - PubMed
    1. Furuzawa-Carballeda J, Torres-Landa S, Valdovinos MÁ, et al. New insights into the pathophysiology of achalasia and implications for future treatment. World J Gastroenterol 2016; 22: 7892–7907. - PMC - PubMed

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