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. 2017 Jun 26;8(7):3449-3457.
doi: 10.1364/BOE.8.003449. eCollection 2017 Jul 1.

Photoacoustic/ultrasound dual imaging of human thyroid cancers: an initial clinical study

Meng Yang  1   2 , Lingyi Zhao  3   2 , Xujin He  4 , Na Su  1 , ChenYang Zhao  1 , Hewen Tang  1 , Tao Hong  5 , Wenbo Li  1 , Fang Yang  4 , Lin Lin  1 , Bing Zhang  1 , Rui Zhang  1 , Yuxin Jiang  1 , Changhui Li  3
Affiliations

Photoacoustic/ultrasound dual imaging of human thyroid cancers: an initial clinical study

Meng Yang et al. Biomed Opt Express. .

Abstract

We reported an initial clinical study of in vivo human thyroid by a photoacoustic/ultrasound handheld probe. Our dual-modality system is based on a high-end clinical ultrasound machine. Both healthy and cancerous thyroids were imaged non-invasively, and we compared the photoacoustic imaging with color Doppler ultrasound. The results of photoacoustic thyroid imaging could reveal many blood vessels that were not sensitive for Doppler ultrasound. Our study demonstrated that photoacoustic imaging could provide important complementary information for traditional ultrasound thyroid examination, which has a great potential for clinical diagnosis.

Keywords: (110.5120) Photoacoustic imaging; (170.1610) Clinical applications; (170.5120) Photoacoustic imaging.

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Figures

Fig. 1
Fig. 1
PA/US imaging system. (a) Schematic. (b) Photograph of the prototype system.
Fig. 2
Fig. 2
Dual-modality handheld probe. (a) Schematic. (b) Photograph.
Fig. 3
Fig. 3
Dual-modality imaging results of a carbon rod hanged in intralipid solution with different orientation angles (a-c), and different depths (d-f). US results are in gray, and PAI results are in color.
Fig. 4
Fig. 4
Imaging results of human forearm cutaneous vein with longitude section and transverse sections. (a) CDFI result with longitude section; (b) gray scale US B-scan with longitude section; (c) PA/US imaging with longitude section; (d) CDFI result with transverse section; (e) gray scale US B-scan with transverse section; (f) PA/US imaging with transverse section;
Fig. 5
Fig. 5
Imaging results for a healthy right thyroid. (a) CDFI result; (b) gray scale US B-scan; and (c) PA/US imaging result. GP (gel pad), SK (skin), MU (muscle), CA (carotid), TH (thyroid), TR (trachea), VE (vertebrae).
Fig. 6
Fig. 6
Imaging results for a left lobe papillary thyroid cancer (PTC, Follicular variation) with the largest diameter of 9 mm. (a) CDFI result; (b) gray scale US B-scan; and (c) PA/US imaging result. Solid white arrow indicates left lobe PTC, and dashed white arrows indicate suspected feeding vessels.
Fig. 7
Fig. 7
Imaging results for a right lobe PTC with the largest diameter of 13 mm. (a) CDFI result; (b) gray scale US B-scan; and (c) PA/US imaging result. White arrow indicates right lobe PTC.
Fig. 8
Fig. 8
Imaging results for a left lobe papillary thyroid cancer (PTC, Follicular variation) with the largest diameter of 3 mm. (a) CDFI result; (b) gray scale US B-scan; and (c) PA/US imaging result. White arrow indicates the left lobe PTC.
See this image and copyright information in PMC

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