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. 1986 May;123(2):250-5.

Immunoreactive somatostatin in Warthin's tumor

Y Hayashi, H Saito, S Saito, T Yanagawa, H Yoshida, Y Yura, M Sato

Immunoreactive somatostatin in Warthin's tumor

Y Hayashi et al. Am J Pathol. 1986 May.

Abstract

The presence of somatostatin (SRIF) in the neoplastic epithelial cells of certain Warthin's tumors arising in the human parotid gland was found immunohistochemically, whereas the other parotid gland tumors, such as pleomorphic adenoma, oxyphilic adenoma, mucoepidermoid tumor, adenocarcinoma, and adenoid cystic carcinoma, did not show positive immunoreactivity for SRIF. The SRIF-positive Warthin's tumor had dense core granules immunoreactive with anti-SRIF serum. Moreover, a comparatively high concentration of immunoreactive SRIF was detected by radioimmunoassay in an SRIF-positive Warthin's tumor, although the other tumors also contained low levels of immunoreactive SRIF.

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