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. 2016 Jan 13;2(1):47-50.
doi: 10.1200/JGO.2015.001701. eCollection 2016 Feb.

Collision of Three Pandemics: The Coexistence of Cervical Cancer, HIV Infection, and Prior Tuberculosis in the Sub-Saharan Country of Botswana

Nicola M Zetola  1 , Surbhi Grover  1 , Chawangwa Modongo  1 , Sebathu P Chiyapo  1 , Memory Nsingo-Bvochora  1 , Mohan Narasimhamurthy  1 , Lilie L Lin  1 , Joseph Jarvis  1 , Sanghyuk S Shin  1 , Erle Robertson  1
Affiliations

Collision of Three Pandemics: The Coexistence of Cervical Cancer, HIV Infection, and Prior Tuberculosis in the Sub-Saharan Country of Botswana

Nicola M Zetola et al. J Glob Oncol. .

Abstract

Cervical cancer is the leading cause of cancer-related mortality in the developing world, where HIV and Mycobacterium tuberculosis (TB) infection are also endemic. HIV infection is independently associated with increased morbidity and mortality among women with cervical cancer. TB is believed to increase the risk of malignancies and could cause chronic inflammation in the gynecologic tract. However, the relationship between cervical cancer and TB in settings hyperendemic for HIV is unknown. We found that 18 (10%) of a cohort of 180 women with cervical cancer in Botswana had a history of TB disease. Age and HIV infection were also associated with a history of TB disease. Our data show that prior TB disease is highly prevalent among patients with cervical cancer infected with HIV. The coexistence of cervical cancer, HIV infection, and prior TB infection might be higher than expected in the general population. Prospective studies are needed to better determine the impact of the collision of these three world health epidemics.

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Conflict of interest statement

Authors’ disclosures of potential conflicts of interest and contributions are found at the end of this article. The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or jco.ascopubs.org/site/ifc. Nicola M. ZetolaNo relationship to discloseSurbhi GroverNo relationship to discloseChawangwa ModongoNo relationship to discloseSebathu P. ChiyapoNo relationship to discloseMemory Nsingo-BvochoraSpeakers' Bureau: AstraZeneca Travel, Accommodations, Expenses: Roche, AstraZenecaMohan NarasimhamurthyNo relationship to discloseLilie L. LinSpeakers' Bureau: Varian Medical Systems Research Funding: Varian Medical SystemsJoseph JarvisResearch Funding: Gilead SciencesSanghyuk S. ShinEmployment: Beckman CoulterErle RobertsonNo relationship to disclose

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