Secondary Necrosis: Accidental No More

Lorenzo Galluzzi¹, Guido Kroemer²

Affiliations

¹ Department of Radiation Oncology, Weill Cornell Medical College, New York, NY 10065, USA; Equipe 11 Labellisée par la Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France; INSERM, U1138, 75006 Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France; Université Pierre et Marie Curie/Paris VI, 75006 Paris, France; Gustave Roussy Comprehensive Cancer Institute, 94805 Villejuif, France. Electronic address: deadoc@vodafone.it.
² Equipe 11 Labellisée par la Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France; INSERM, U1138, 75006 Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France; Université Pierre et Marie Curie/Paris VI, 75006 Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, 94805 Villejuif, France; Pôle de Biologie, Hopitâl Européen George Pompidou, AP-HP, 75015 Paris, France; Department of Women's and Children's Health, Karolinska University Hospital, 17176 Stockholm, Sweden.

PMID: 28718422
DOI: 10.1016/j.trecan.2016.12.001

Comment

Secondary Necrosis: Accidental No More

Lorenzo Galluzzi et al. Trends Cancer. 2017 Jan.

. 2017 Jan;3(1):1-2.

doi: 10.1016/j.trecan.2016.12.001. Epub 2017 Jan 3.

Authors

Lorenzo Galluzzi¹, Guido Kroemer²

Affiliations

¹ Department of Radiation Oncology, Weill Cornell Medical College, New York, NY 10065, USA; Equipe 11 Labellisée par la Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France; INSERM, U1138, 75006 Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France; Université Pierre et Marie Curie/Paris VI, 75006 Paris, France; Gustave Roussy Comprehensive Cancer Institute, 94805 Villejuif, France. Electronic address: deadoc@vodafone.it.
² Equipe 11 Labellisée par la Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France; INSERM, U1138, 75006 Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France; Université Pierre et Marie Curie/Paris VI, 75006 Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, 94805 Villejuif, France; Pôle de Biologie, Hopitâl Européen George Pompidou, AP-HP, 75015 Paris, France; Department of Women's and Children's Health, Karolinska University Hospital, 17176 Stockholm, Sweden.

PMID: 28718422
DOI: 10.1016/j.trecan.2016.12.001

Abstract

Recent data demonstrate that secondary necrosis is not an accidental epiphenomenon of apoptosis, but a finely regulated process with prominent pathophysiological and therapeutic implications. The molecular machinery that controls secondary necrosis stands out as a promising target for the development of novel drugs that may increase the immunogenicity of cancer cells succumbing to treatment.

Keywords: DFNA5; GSDMD; caspases; danger signaling; necroptosis; pyroptosis.

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Comment on

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death.
Rogers C, Fernandes-Alnemri T, Mayes L, Alnemri D, Cingolani G, Alnemri ES. Rogers C, et al. Nat Commun. 2017 Jan 3;8:14128. doi: 10.1038/ncomms14128. Nat Commun. 2017. PMID: 28045099 Free PMC article.

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Secondary Necrosis: Accidental No More

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Secondary Necrosis: Accidental No More

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