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Comment
. 2017 Mar;3(3):161-163.
doi: 10.1016/j.trecan.2017.01.004. Epub 2017 Jan 30.

IFN Signaling and ICB Resistance: Time is on Tumor's Side

Alejandro López-Soto  1 , Segundo Gonzalez  2 , Alicia R Folgueras  3
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Comment

IFN Signaling and ICB Resistance: Time is on Tumor's Side

Alejandro López-Soto et al. Trends Cancer. 2017 Mar.

Abstract

Activation of antitumor immunity upon immune checkpoint blockade (ICB) is one of the most promising strategies in cancer therapy. However, ICB resistance is frequently observed in cancer preclinical models and patients. A recent report in Cell reveals that sustained interferon (IFN) signaling confers tumor resistance to ICB by inducing the expression of an immunosuppressive multigenic program.

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