Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jun:3:149-154.
doi: 10.1016/j.pvr.2017.04.006. Epub 2017 May 5.

Human papillomavirus in anal biopsy tissues and liquid-based cytology samples of HIV-positive and HIV-negative Thai men who have sex with men

Tippawan Pankam  1 , Stephen J Kerr  2 , Nipat Teeratakulpisan  3 , Piyanee Rodbamrung  3 , Rapeeporn Wongkanya  3 , Somboon Keelawat  4 , Komkrit Ruangritchankul  5 , Piranun Hongchookiat  3 , Ramida Watanapokasin  6 , Nittaya Phanuphak  7
Affiliations

Human papillomavirus in anal biopsy tissues and liquid-based cytology samples of HIV-positive and HIV-negative Thai men who have sex with men

Tippawan Pankam et al. Papillomavirus Res. 2017 Jun.

Abstract

Background: Men who have sex with men (MSM) are at high risk of developing human papillomavirus (HPV)-related anal cancer. We compared HPV genotypes in anal tissues (Bx) and anal liquid-based cytology fluid (LBC) from HIV-positive and HIV-negative MSM.

Methods: Bx (32 normal, 41 low-grade squamous intraepithelial lesions (LSIL) and 22 high-grade squamous intraepithelial lesions (HSIL)), along with LBC from the same visit, were selected from 61 HIV-positive and 34 HIV-negative MSM who enrolled into a prospective cohort in Bangkok, Thailand. HPV genotyping was performed on Bx and LBC.

Results: Any HPV and high-risk HPV (HR-HPV) prevalence were 63.2% and 60.0% in Bx and 71.6% and 62.1% in LBC, respectively. HIV-positive MSM had higher rates of HR-HPV genotypes detection (70.5% vs. 47.1%, p=0.03) in LBC than HIV-negative MSM. HPV16 (27%) was the most common HR-HPV found in HSIL tissue. In HIV-positive MSM, the frequency of HR-HPV detection increased with histopathologic grading in both Bx and LBC samples. HSIL was associated with the presence of any HR-HPV(OR 7.6 (95%CI 1.8-31.9); P=0.006) in LBC and in Bx((OR 5.6 (95%CI 1.4-22.7); P=0.02).

Conclusions: Our data strongly support the integration of HR-HPV screening on LBC samples, along with HPV vaccination, into an anal cancer prevention program.

Keywords: Anal tissues; HIV; Human papillomavirus; Men who have sex with men; Thailand.

PubMed Disclaimer

References

    1. Silverberg M.J., Lau B., Justice A.C., Engels E., Gill M.J., Goedert J.J. Risk of anal cancer in HIV-infected and HIV-uninfected individuals in North America. Clin. Infect. Dis. 2012;54(7):1026–1034. (Epub 2012/02/01) - PMC - PubMed
    1. Piketty C., Selinger-Leneman H., Grabar S., Duvivier C., Bonmarchand M., Abramowitz L. Marked increase in the incidence of invasive anal cancer among HIV-infected patients despite treatment with combination antiretroviral therapy. AIDS. 2008;22(10):1203–1211. (Epub 2008/06/06) - PubMed
    1. D'Souza G., Wiley D.J., Li X., Chmiel J.S., Margolick J.B., Cranston R.D. Incidence and epidemiology of anal cancer in the multicenter AIDS cohort study. J. Acquir Immune Defic. Syndr. 2008;48(4):491–499. (Epub 2008/07/11) - PMC - PubMed
    1. Alvarez-Arguelles M.E., Melon S., Junquera M.L., Boga J.A., Villa L., Perez-Castro S. Human papillomavirus infection in a male population attending a sexually transmitted infection service. PloS One. 2013;8(1):e54375. (Epub 2013/02/02) - PMC - PubMed
    1. Moody C.A., Laimins L.A. Human papillomavirus oncoproteins: pathways to transformation. Nat. Rev. Cancer. 2010;10(8):550–560. (Epub 2010/07/02) - PubMed

LinkOut - more resources