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. 2017 Jun 29:12:1041-1048.
doi: 10.2147/CIA.S132884. eCollection 2017.

11C-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer's disease in the absence of known mutations retains higher levels of PIB in the basal ganglia

Young Chul Youn  1 , Jae-Won Jang  2 , Su-Hyun Han  1 , HyeRyoun Kim  3 , Ju-Won Seok  4 , Jun Soo Byun  5 , Kwang-Yeol Park  1 , Seong Soo A An  6 , In Kook Chun  7 , SangYun Kim  8
Affiliations

11C-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer's disease in the absence of known mutations retains higher levels of PIB in the basal ganglia

Young Chul Youn et al. Clin Interv Aging. .

Abstract

Purpose: Early-onset Alzheimer's disease (EOAD) has a different pathologic burden and clinical features compared with late-onset Alzheimer's disease (LOAD). We examined the effects of age at onset on the burden and distribution of β-amyloid in patients with EOAD, in whom well-characterized mutations associated with Alzheimer's disease were absent.

Methods: We genotyped ApoE, APP, PSEN1 and PSEN2 in the patients with Alzheimer's disease: 9 patients with EOAD (age <65), 11 with LOAD (age >70) and 8 normal controls (NCs), all of whom had undergone 11C-labeled Pittsburgh compound B-positron emission tomography imaging.

Results: Patients with EOAD exhibited higher z scores and larger cluster sizes, and retained higher levels of Pittsburgh compound B in the bilateral thalamus and in some parts of the globus pallidus (P<0.05, false discovery rate).

Conclusion: Distribution of amyloid deposition in EOAD outside the context of genetic mutations topographically showed some differences from that in LOAD.

Keywords: Alzheimer’s disease; Pittsburgh compound B; amyloid; amyloid PET; basal ganglia; early-onset Alzheimer’s disease.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Statistical parametric maps (P<0.05, FDR; extent threshold =50 voxels) of Pittsburgh compound B retention in (A) the EOAD group compared with the NC group, (B) the LOAD group compared with the NC group and (C) the EOAD group compared with the LOAD group. The color scale indicates the z value magnitude, with the lowest value appearing in dark red and the highest value in bright yellow/white. Abbreviations: EOAD, early-onset Alzheimer’s disease; FDR, false discovery rate; LOAD, late-onset Alzheimer’s disease; NC, normal control.
Figure 1
Figure 1
Statistical parametric maps (P<0.05, FDR; extent threshold =50 voxels) of Pittsburgh compound B retention in (A) the EOAD group compared with the NC group, (B) the LOAD group compared with the NC group and (C) the EOAD group compared with the LOAD group. The color scale indicates the z value magnitude, with the lowest value appearing in dark red and the highest value in bright yellow/white. Abbreviations: EOAD, early-onset Alzheimer’s disease; FDR, false discovery rate; LOAD, late-onset Alzheimer’s disease; NC, normal control.
Figure 1
Figure 1
Statistical parametric maps (P<0.05, FDR; extent threshold =50 voxels) of Pittsburgh compound B retention in (A) the EOAD group compared with the NC group, (B) the LOAD group compared with the NC group and (C) the EOAD group compared with the LOAD group. The color scale indicates the z value magnitude, with the lowest value appearing in dark red and the highest value in bright yellow/white. Abbreviations: EOAD, early-onset Alzheimer’s disease; FDR, false discovery rate; LOAD, late-onset Alzheimer’s disease; NC, normal control.
See this image and copyright information in PMC

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