Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Dec;32(6):1843-1851.
doi: 10.1007/s11011-017-0066-5. Epub 2017 Jul 18.

Anatomical specificity of the brain in the modulation of Neuroglobin and Cytoglobin genes after chronic bisphenol a exposure

Rodrigo Rodrigues da Conceição  1 , Janaina Sena de Souza  1 , Kelen Carneiro de Oliveira  1 , Rui Monteiro de Barros Maciel  1 , Marco Aurélio Romano  2 , Renata Marino Romano  2 , Magnus Régios Dias da Silva  1 , Maria Izabel Chiamolera  1 , Gisele Giannocco  3   4   5
Affiliations

Anatomical specificity of the brain in the modulation of Neuroglobin and Cytoglobin genes after chronic bisphenol a exposure

Rodrigo Rodrigues da Conceição et al. Metab Brain Dis. 2017 Dec.

Erratum in

Abstract

The aim of this study was to investigate the influence of Bisphenol A (BPA) exposure on Neuroglobin (Ngb) and Cytoglobin (Cygb) as well as oxidative stress gene expression in the cerebellum, hippocampus, hypothalamus and cortex. Male Wistar rats were randomly divided into 3 groups: Control and two groups receiving 2 different daily BPA dosages, 5 or 25 mg/kg from postnatal day 50 (PND50) through PND90 and they were euthanized at PND105. In the cortex, we found an increase in Ngb gene expression and also in superoxide dismutase 1 and Catalase (Cat). In the cerebellum, we found an increase in Ngb and Cat, in the hypothalamus, there was a decrease in Cygb and an increase in glutathione peroxidase and Cat and in hypoxia-inducible factor 1 alpha (Hif1α) at the low dosage and a decrease in Hif1α at the high BPA dosage. Finally, in the hippocampus, we observed a decrease in Ngb and Cygb and an increase in Hif1α. In summary, BPA promotes the modulation of both Ngb and Cygb, but such changes occur by different mechanisms depending on the exposure dose and anatomical area.

Keywords: Bisphenol a; Brain; Cytoglobin; Neuroglobin; Reactive oxygen species.

PubMed Disclaimer

References

    1. Biochim Biophys Acta. 2011 Jul;1813(7):1263-8 - PubMed
    1. Neuroreport. 2013 Feb 13;24(3):120-5 - PubMed
    1. Toxicology. 2009 Feb 4;256(1-2):7-12 - PubMed
    1. Antioxid Redox Signal. 2010 Sep 15;13(6):769-81 - PubMed
    1. Mol Biol Evol. 2002 Apr;19(4):416-21 - PubMed

LinkOut - more resources