The efficacy of pefloxacin in comparison to gentamicin in the treatment of experimentally induced peritonitis in rats

Abstract

A reproducible experimental model of intra-abdominal infections in rats has been devised in order to stimulate intra-abdominal sepsis in patients. Pre-operatively, the rats were fed with lean ground beef for two weeks in order to change the intestinal flora to one similar to that of humans. A 1 cm segment of ileum was isolated on its vascular pedicle. The intestine was then divided at each end of the segment and intestinal continuity was re-established by an end-to-end anastomosis. The segment of ileum was then returned to the abdominal cavity. This experimental model was used to compare the efficacy of pefloxacin alone and in combination with metronidazole with the combination gentamicin and metronidazole in the treatment of intra-abdominal infections. Seventy per cent of the untreated animals died within two days. Within three days 40% of the animals receiving pefloxacin died. Animals treated with pefloxacin plus metronidazole or gentamicin plus metronidazole had a significantly decreased mortality and increased cure rates during the experimental period. Only 5% of these animals died. Thus the combination of pefloxacin and metronidazole seems to be as successful as gentamicin plus metronidazole in the treatment of intra-abdominal infections.