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Editorial
. 2017 Aug 18;16(16):1483-1484.
doi: 10.1080/15384101.2017.1345238. Epub 2017 Jul 19.

An HSP90 co-chaperone controls circadian proteostasis

Jeongsik Kim  1 , David E Somers  2
Affiliations
Editorial

An HSP90 co-chaperone controls circadian proteostasis

Jeongsik Kim et al. Cell Cycle. .
No abstract available

Keywords: GIGANTEA; HSP90; ZEITLUPE; circadian clocks; co-chaperone; proteostasis.

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Figures

Figure 1.
Figure 1.
Model of the HSP90 chaperone cycle with the co-chaperone GIGANTEA acting on the client ZEITLUPE. Nascent ZTL is likely to first interact with HSP40/HSP70. GI is proposed to help introduce ZTL into the HSP90 chaperone cycle via interaction with the N-terminal LOV domain. Subsequently, an HSP90-GI-ZTL complex forms to facilitate maturation of ZTL. Not shown is the effect of blue light in facilitating the initial GI-ZTL interaction.
See this image and copyright information in PMC

Comment on

References

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    1. Cha JY, Kim J, Kim TS, Zeng Q, Wang L, Lee SY, Kim WY, Somers DE. GIGANTEA is a co-chaperone which facilitates maturation of ZEITLUPE in the Arabidopsis circadian clock. Nat Commun 2017; 8:3; http://doi.org/b7vw; PMID:28232745; https://doi.org/10.1038/s41467-016-0014-9 - DOI - PMC - PubMed

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