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Papular acrodermatitis of childhood, otherwise known as Gianotti-Crosti syndrome, is a benign rash associated with various viral illnesses. Although historically thought to be solely a manifestation of hepatitis B infection, it has been demonstrated to occur following many viral illnesses and vaccination, which suggests that this is an immunologic response rather than a primary manifestation of infection. Papular acrodermatitis of childhood is characterized by the acute eruption of monomorphic skin-colored to pink-red papules on the face, buttocks, and extensor surfaces of the extremities. The lesions usually spontaneously resolve, and treatment is supportive.
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Pedreira RL, Leal JM, Silvestre KJ, Lisboa AP, Gripp AC. Gianotti-Crosti syndrome: a case report of a teenager. An Bras Dermatol. 2016 Sep-Oct;91(5 suppl 1):163-165.
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Drago F, Javor S, Ciccarese G, Parodi A. Gianotti-Crosti syndrome as presenting sign of cytomegalovirus infection: A case report and a critical appraisal of its possible cytomegalovirus etiology. J Clin Virol. 2016 May;78:120-2.
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