Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Book

Long QT Syndrome

Mohammad Al-Akchar  1 , Momin S. Siddique  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
Affiliations
Free Books & Documents
Book

Long QT Syndrome

Mohammad Al-Akchar et al.
Free Books & Documents

Excerpt

The QT interval on an electrocardiogram (ECG) represents the duration of the ventricular action potential, and this physiologically correlates with the duration of the ventricular depolarization and repolarization. Cardiac events and fatal arrhythmias may occur when the QT interval is prolonged either congenitally or through acquired causes.

PubMed Disclaimer

Conflict of interest statement

Disclosure: Mohammad Al-Akchar declares no relevant financial relationships with ineligible companies.

Disclosure: Momin Siddique declares no relevant financial relationships with ineligible companies.

References

    1. Zhou X, Bueno-Orovio A, Schilling RJ, Kirkby C, Denning C, Rajamohan D, Burrage K, Tinker A, Rodriguez B, Harmer SC. Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D. Front Physiol. 2019;10:259. - PMC - PubMed
    1. Dehghani-Samani A, Madreseh-Ghahfarokhi S, Dehghani-Samani A. Mutations of Voltage-Gated Ionic Channels and Risk of Severe Cardiac Arrhythmias. Acta Cardiol Sin. 2019 Mar;35(2):99-110. - PMC - PubMed
    1. Alahmadi A, Davies A, Vigo M, Jay C. Can laypeople identify a drug-induced QT interval prolongation? A psychophysical and eye-tracking experiment examining the ability of nonexperts to interpret an ECG. J Am Med Inform Assoc. 2019 May 01;26(5):404-411. - PMC - PubMed
    1. Giudicessi JR, Roden DM, Wilde AAM, Ackerman MJ. Classification and Reporting of Potentially Proarrhythmic Common Genetic Variation in Long QT Syndrome Genetic Testing. Circulation. 2018 Feb 06;137(6):619-630. - PMC - PubMed
    1. Beach SR, Celano CM, Sugrue AM, Adams C, Ackerman MJ, Noseworthy PA, Huffman JC. QT Prolongation, Torsades de Pointes, and Psychotropic Medications: A 5-Year Update. Psychosomatics. 2018 Mar-Apr;59(2):105-122. - PubMed

Publication types

LinkOut - more resources