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. 1986 Apr;38(4):301-3.
doi: 10.1111/j.2042-7158.1986.tb04572.x.

Amineptine: its effect on the dopaminergic system of rats

F Ponzio, G Achilli, S Garattini, C Perego, G Sacchetti, S Algeri

Amineptine: its effect on the dopaminergic system of rats

F Ponzio et al. J Pharm Pharmacol. 1986 Apr.

Abstract

3-Methoxytyramine formation was enhanced by amineptine (40 mg kg-1 i.p.) in the striatum and limbic area, indicating an increase in the concentration of dopamine in the extraneuronal space. Since dopamine turnover, determined as the rate of L-dopa accumulation, is reduced by the drug at short (10 min) times, the enhanced extraneuronal dopamine concentration seems mainly related to amineptine-induced inhibition of its uptake.

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