Necroptosis: (Last) Message in a Bubble

Peter Vandenabeele¹, Franck Riquet², Benjamin Cappe³

Affiliations

¹ Molecular Signaling and Cell Death Unit, VIB Inflammation Research Center, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; Methusalem Program, Ghent University, Ghent, Belgium. Electronic address: peter.vandenabeele@irc.vib-ugent.be.
² Molecular Signaling and Cell Death Unit, VIB Inflammation Research Center, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; Unité de Glycobiologie Structurale et Fonctionnelle, CNRS-UMR 8576, Université Lille1, Villeneuve d'Ascq, France.
³ Molecular Signaling and Cell Death Unit, VIB Inflammation Research Center, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.

PMID: 28723543
DOI: 10.1016/j.immuni.2017.07.002

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Necroptosis: (Last) Message in a Bubble

Peter Vandenabeele et al. Immunity. 2017.

Free article

. 2017 Jul 18;47(1):1-3.

doi: 10.1016/j.immuni.2017.07.002.

Authors

Peter Vandenabeele¹, Franck Riquet², Benjamin Cappe³

Affiliations

¹ Molecular Signaling and Cell Death Unit, VIB Inflammation Research Center, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; Methusalem Program, Ghent University, Ghent, Belgium. Electronic address: peter.vandenabeele@irc.vib-ugent.be.
² Molecular Signaling and Cell Death Unit, VIB Inflammation Research Center, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; Unité de Glycobiologie Structurale et Fonctionnelle, CNRS-UMR 8576, Université Lille1, Villeneuve d'Ascq, France.
³ Molecular Signaling and Cell Death Unit, VIB Inflammation Research Center, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.

PMID: 28723543
DOI: 10.1016/j.immuni.2017.07.002

Abstract

RIPK3 kinase-mediated phosphorylation of MLKL pseudokinase is the execution event of necroptosis. Two independent reports-in Immunity (Yoon et al., 2017) and Cell (Gong et al., 2017)-reveal that MLKL affects homeostatic membrane trafficking and necroptosis-enhanced bubble formation involving interaction with the ESCRT machinery.

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ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences.
Gong YN, Guy C, Olauson H, Becker JU, Yang M, Fitzgerald P, Linkermann A, Green DR. Gong YN, et al. Cell. 2017 Apr 6;169(2):286-300.e16. doi: 10.1016/j.cell.2017.03.020. Cell. 2017. PMID: 28388412 Free PMC article.
MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation.
Yoon S, Kovalenko A, Bogdanov K, Wallach D. Yoon S, et al. Immunity. 2017 Jul 18;47(1):51-65.e7. doi: 10.1016/j.immuni.2017.06.001. Epub 2017 Jun 27. Immunity. 2017. PMID: 28666573

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Necroptosis: (Last) Message in a Bubble

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Necroptosis: (Last) Message in a Bubble

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