Spineless Behavior of CX3CR1+ Monocytes in Response to Infection
- PMID: 28723545
- DOI: 10.1016/j.immuni.2017.06.022
Spineless Behavior of CX3CR1+ Monocytes in Response to Infection
Abstract
Sickness in mammals can lead to cognition deficits, although the underlying mechanisms remain elusive. In a recent Nature Medicine article, Garré et al. (2017) report that sickness-induced cortical dendritic spine loss and impaired memory formation is mediated by CX3CR1+ monocyte-derived TNF-α.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
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CX3CR1+ monocytes modulate learning and learning-dependent dendritic spine remodeling via TNF-α.Nat Med. 2017 Jun;23(6):714-722. doi: 10.1038/nm.4340. Epub 2017 May 15. Nat Med. 2017. PMID: 28504723 Free PMC article.
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