The Human Virome: Implications for Clinical Practice in Transplantation Medicine

doi:10.1128/JCM.00489-17

Review

. 2017 Oct;55(10):2884-2893.

doi: 10.1128/JCM.00489-17. Epub 2017 Jul 19.

The Human Virome: Implications for Clinical Practice in Transplantation Medicine

Susanna K Tan¹, David A Relman^{2

3

4}, Benjamin A Pinsky^{2

5}

Affiliations

¹ Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA susietan@stanford.edu.
² Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA.
³ Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
⁴ Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
⁵ Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.

PMID: 28724557
PMCID: PMC5625374
DOI: 10.1128/JCM.00489-17

Review

The Human Virome: Implications for Clinical Practice in Transplantation Medicine

Susanna K Tan et al. J Clin Microbiol. 2017 Oct.

. 2017 Oct;55(10):2884-2893.

doi: 10.1128/JCM.00489-17. Epub 2017 Jul 19.

Authors

Susanna K Tan¹, David A Relman^{2

3

4}, Benjamin A Pinsky^{2

5}

Affiliations

¹ Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA susietan@stanford.edu.
² Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA.
³ Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
⁴ Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
⁵ Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.

PMID: 28724557
PMCID: PMC5625374
DOI: 10.1128/JCM.00489-17

Abstract

Advances in DNA sequencing technology have provided an unprecedented opportunity to study the human virome. Transplant recipients and other immunocompromised hosts are at particular risk for developing virus-related pathology; thus, the impact of the virome on health and disease may be even more relevant in this population. Here, we discuss technical considerations in studying the human virome, the current literature on the virome in transplant recipients, and near-future applications of sequence-based findings that can further our understanding of viruses in transplantation medicine.

Keywords: immunocompromised hosts; transplantation; virome.

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References

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[1] Columpsi P, Sacchi P, Zuccaro V, Cima S, Sarda C, Mariani M, Gori A, Bruno R. 2016. Beyond the gut bacterial microbiota: the gut virome. J Med Virol 88:1467–1472. doi:10.1002/jmv.24508. - DOI - PMC - PubMed

[2] Columpsi P, Sacchi P, Zuccaro V, Cima S, Sarda C, Mariani M, Gori A, Bruno R. 2016. Beyond the gut bacterial microbiota: the gut virome. J Med Virol 88:1467–1472. doi:10.1002/jmv.24508. - DOI - PMC - PubMed

[3] Wylie KM. 2017. The virome of the human respiratory tract. Clin Chest Med 38:11–19. doi:10.1016/j.ccm.2016.11.001. - DOI - PMC - PubMed

[4] Wylie KM. 2017. The virome of the human respiratory tract. Clin Chest Med 38:11–19. doi:10.1016/j.ccm.2016.11.001. - DOI - PMC - PubMed

[5] Pride DT, Salzman J, Haynes M, Rohwer F, Davis-Long C, RAWhite III, Loomer P, Armitage GC, Relman DA. 2012. Evidence of a robust resident bacteriophage population revealed through analysis of the human salivary virome. ISME J 6:915–926. doi:10.1038/ismej.2011.169. - DOI - PMC - PubMed

[6] Pride DT, Salzman J, Haynes M, Rohwer F, Davis-Long C, RAWhite III, Loomer P, Armitage GC, Relman DA. 2012. Evidence of a robust resident bacteriophage population revealed through analysis of the human salivary virome. ISME J 6:915–926. doi:10.1038/ismej.2011.169. - DOI - PMC - PubMed

[7] Sauvage V, Eloit M. 2016. Viral metagenomics and blood safety. Transfus Clin Biol 23:28–38. doi:10.1016/j.tracli.2015.12.002. - DOI - PMC - PubMed

[8] Sauvage V, Eloit M. 2016. Viral metagenomics and blood safety. Transfus Clin Biol 23:28–38. doi:10.1016/j.tracli.2015.12.002. - DOI - PMC - PubMed

[9] Santiago-Rodriguez TM, Ly M, Bonilla N, Pride DT. 2015. The human urine virome in association with urinary tract infections. FrontMicrobiol 6:14. - PMC - PubMed

[10] Santiago-Rodriguez TM, Ly M, Bonilla N, Pride DT. 2015. The human urine virome in association with urinary tract infections. FrontMicrobiol 6:14. - PMC - PubMed

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The Human Virome: Implications for Clinical Practice in Transplantation Medicine

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The Human Virome: Implications for Clinical Practice in Transplantation Medicine

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