Meta-Analysis

. 2017 Jul 19;8(1):80.

doi: 10.1038/s41467-017-00031-7.

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

M Carola Zillikens^{1

2}, Serkalem Demissie³, Yi-Hsiang Hsu^{4

5

6}, Laura M Yerges-Armstrong⁷, Wen-Chi Chou^{4

5

8}, Lisette Stolk^{1

2}, Gregory Livshits^{9

10}, Linda Broer¹¹, Toby Johnson^{12

13

14}, Daniel L Koller¹⁵, Zoltán Kutalik^{12

13

14}, Jian'an Luan¹⁶, Ida Malkin⁹, Janina S Ried¹⁷, Albert V Smith^{18

19}, Gudmar Thorleifsson²⁰, Liesbeth Vandenput²¹, Jing Hua Zhao¹⁶, Weihua Zhang^{22

23}, Ali Aghdassi²⁴, Kristina Åkesson^{25

26}, Najaf Amin¹¹, Leslie J Baier²⁷, Inês Barroso^{28

29

30}, David A Bennett³¹, Lars Bertram^{32

33}, Rainer Biffar³⁴, Murielle Bochud¹⁴, Michael Boehnke³⁵, Ingrid B Borecki^{36

37}, Aron S Buchman³¹, Liisa Byberg³⁸, Harry Campbell³⁹, Natalia Campos Obanda¹, Jane A Cauley⁴⁰, Peggy M Cawthon⁴¹, Henna Cederberg⁴², Zhao Chen⁴³, Nam H Cho⁴⁴, Hyung Jin Choi^{45

46}, Melina Claussnitzer^{4

5

8

47

48

49}, Francis Collins⁵⁰, Steven R Cummings⁴¹, Philip L De Jager^{5

51

52}, Ilja Demuth^{53

54}, Rosalie A M Dhonukshe-Rutten⁵⁵, Luda Diatchenko^{56

57}, Gudny Eiriksdottir¹⁸, Anke W Enneman¹, Mike Erdos⁵⁰, Johan G Eriksson^{58

59

60

61

62}, Joel Eriksson²¹, Karol Estrada^{1

11}, Daniel S Evans⁴¹, Mary F Feitosa³⁶, Mao Fu⁷, Melissa Garcia⁶³, Christian Gieger^{17

64

65}, Thomas Girke^{66

67}, Nicole L Glazer⁶⁸, Harald Grallert^{17

64

67

69

70

71}, Jagvir Grewal^{23

72}, Bok-Ghee Han⁷³, Robert L Hanson²⁷, Caroline Hayward⁷⁴, Albert Hofman^{2

11}, Eric P Hoffman⁷⁵, Georg Homuth⁷⁶, Wen-Chi Hsueh²⁷, Monica J Hubal^{77

78}, Alan Hubbard⁷⁹, Kim M Huffman⁸⁰, Lise B Husted⁸¹, Thomas Illig^{64

82

83}, Erik Ingelsson^{84

85}, Till Ittermann⁸⁶, John-Olov Jansson⁸⁷, Joanne M Jordan⁸⁸, Antti Jula⁶², Magnus Karlsson⁸⁹, Kay-Tee Khaw⁹⁰, Tuomas O Kilpeläinen^{16

91

92}, Norman Klopp^{64

83}, Jacqueline S L Kloth¹, Heikki A Koistinen^{93

94

95

96}, William E Kraus⁹⁷, Stephen Kritchevsky⁹⁸, Teemu Kuulasmaa⁴², Johanna Kuusisto⁴², Markku Laakso⁴², Jari Lahti⁹⁹, Thomas Lang¹⁰⁰, Bente L Langdahl⁸¹, Lenore J Launer⁶³, Jong-Young Lee⁷³, Markus M Lerch²⁴, Joshua R Lewis^{101

102}, Lars Lind⁸⁴, Cecilia Lindgren¹⁰³, Yongmei Liu¹⁰⁴, Tian Liu^{105

106}, Youfang Liu⁸⁸, Östen Ljunggren⁸⁴, Mattias Lorentzon²¹, Robert N Luben⁹⁰, William Maixner⁵⁷, Fiona E McGuigan²⁵, Carolina Medina-Gomez^{1

11}, Thomas Meitinger^{48

107}, Håkan Melhus⁸⁴, Dan Mellström²¹, Simon Melov^{108

109}, Karl Michaëlsson³⁸, Braxton D Mitchell^{7

110}, Andrew P Morris^{103

111}, Leif Mosekilde⁸¹, Anne Newman¹¹², Carrie M Nielson¹¹³, Jeffrey R O'Connell⁷, Ben A Oostra^{114

115}, Eric S Orwoll¹¹³, Aarno Palotie^{116

117}, Stephen C J Parker¹¹⁸, Munro Peacock¹¹⁹, Markus Perola^{62

116

120

121}, Annette Peters^{17

64}, Ozren Polasek¹²², Richard L Prince^{101

123}, Katri Räikkönen⁹⁹, Stuart H Ralston¹²⁴, Samuli Ripatti^{116

125

28}, John A Robbins¹²⁶, Jerome I Rotter¹²⁷, Igor Rudan³⁹, Veikko Salomaa⁶², Suzanne Satterfield¹²⁸, Eric E Schadt¹²⁹, Sabine Schipf⁸⁶, Laura Scott³⁵, Joban Sehmi^{23

72}, Jian Shen¹¹³, Chan Soo Shin⁴⁵, Gunnar Sigurdsson^{19

130}, Shad Smith¹³¹, Nicole Soranzo²⁸, Alena Stančáková⁴², Elisabeth Steinhagen-Thiessen⁵³, Elizabeth A Streeten^{7

132}, Unnur Styrkarsdottir²⁰, Karin M A Swart¹³³, Sian-Tsung Tan^{23

72}, Mark A Tarnopolsky¹³⁴, Patricia Thompson¹³⁵, Cynthia A Thomson⁴³, Unnur Thorsteinsdottir^{19

20}, Emmi Tikkanen^{62

116

124}, Gregory J Tranah⁴¹, Jaakko Tuomilehto^{61

136

137

138}, Natasja M van Schoor¹³³, Arjun Verma²³, Peter Vollenweider¹³⁹, Henry Völzke⁸⁶, Jean Wactawski-Wende¹⁴⁰, Mark Walker¹⁴¹, Michael N Weedon¹⁴², Ryan Welch³⁵, H-Erich Wichmann^{17

143

144}, Elisabeth Widen¹¹⁶, Frances M K Williams¹⁰, James F Wilson^{39

74}, Nicole C Wright¹⁴⁵, Weijia Xie¹⁴², Lei Yu³¹, Yanhua Zhou³, John C Chambers^{22

23

146

147}, Angela Döring^{17

148}, Cornelia M van Duijn^{11

115}, Michael J Econs¹⁴⁹, Vilmundur Gudnason^{18

19}, Jaspal S Kooner^{23

72

147}, Bruce M Psaty^{150

151}, Timothy D Spector¹⁰, Kari Stefansson^{19

20}, Fernando Rivadeneira^{1

2

11}, André G Uitterlinden^{1

2

11}, Nicholas J Wareham¹⁶, Vicky Ossowski²⁷, Dawn Waterworth¹⁵², Ruth J F Loos^{16

153

154

155

156}, David Karasik^{4

5

157}, Tamara B Harris⁶³, Claes Ohlsson²¹, Douglas P Kiel^{158

159

160}

Affiliations

¹ Department of Internal Medicine, Erasmus MC, Rotterdam, 3000, The Netherlands.
² Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, 2593, The Netherlands.
³ Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.
⁴ Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.
⁵ Harvard Medical School, Boston, MA, 02115, USA.
⁶ Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, Boston, MA, 02115, USA.
⁷ Program in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
⁸ Broad Institute, Cambridge, MA, 02142, USA.
⁹ Sackler Faculty of Medicine, Department of Anatomy and Anthropology, Tel Aviv University, Tel Aviv, 6997801, Israel.
¹⁰ Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Campus, London, WC2R 2LS, UK.
¹¹ Department of Epidemiology, Erasmus MC, Rotterdam, 3000, The Netherlands.
¹² Department of Medical Genetics, University of Lausanne, Lausanne, 1011, Switzerland.
¹³ Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland.
¹⁴ Centre Hospitalier Universitaire (CHUV), University Institute for Social and Preventive Medicine, Lausanne, 1010, Switzerland.
¹⁵ Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
¹⁶ MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 OQQ, UK.
¹⁷ Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
¹⁸ Icelandic Heart Association, Kopavogur, 201, Iceland.
¹⁹ Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.
²⁰ deCODE Genetics, Reykjavik, 101, Iceland.
²¹ Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SE-405 30, Sweden.
²² Department Epidemiology and Biostatistics, School of Public Health, Imperial College, London, SW7 2AZ, UK.
²³ Cardiology Department, Ealing Hospital NHS Trust, Middlesex, UB1 3HW, UK.
²⁴ Department of Medicine A, University of Greifswald, Greifswald, 17489, Germany.
²⁵ Department of Clinical Sciences, Lund University, Malmö, 22362, Sweden.
²⁶ Department of Orthopedics, Skåne University Hospital, Malmö, S-205 02, Sweden.
²⁷ Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Phoenix, AZ, 85014, USA.
²⁸ Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK.
²⁹ NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 OQQ, UK.
³⁰ Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge Metabolic Research Laboratories, Cambridge, CB2 OQQ, UK.
³¹ Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA.
³² Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Experimental & Integrative Genomics, University of Lübeck, Lübeck, 23562, Germany.
³³ School of Public Health, Faculty of Medicine, Imperial College London, London, W6 8RP, UK.
³⁴ Centre of Oral Health, Department of Prosthetic Dentistry, Gerodontology and Biomaterials, University of Greifswald, Greifswald, 17489, Germany.
³⁵ Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
³⁶ Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, 63110, USA.
³⁷ Division of Biostatistics, Washington University School of Medicine, St Louis, MO, 63110, USA.
³⁸ Department of Surgical Sciences, Uppsala University, Uppsala, 75185, Sweden.
³⁹ Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, EH8 9AG, UK.
⁴⁰ Department of Epidemiology Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
⁴¹ California Pacific Medical Center Research Institute, San Francisco, CA, 94107, USA.
⁴² Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland.
⁴³ Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, 85714, USA.
⁴⁴ Department of Preventive Medicine, Ajou University School of Medicine, Youngtong-Gu, Suwon, 16499, Korea.
⁴⁵ Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 03080, Korea.
⁴⁶ Department of Internal Medicine, Chungbuk National University Hospital, Cheongju Si, Korea.
⁴⁷ Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA, 02139, USA.
⁴⁸ Institute of Human Genetics, MRI, Technische Universität München, Munich, 81675, Germany.
⁴⁹ Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.
⁵⁰ Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, Bethesda, MD, 20892, USA.
⁵¹ Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, MA, 02115, USA.
⁵² Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, 02142, USA.
⁵³ Lipid Clinic at the Interdisciplinary Metabolism Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, 13353, Germany.
⁵⁴ Institute of Medical and Human Genetics, Charité - Universitätsmedizin Berlin, Berlin, 13353, Germany.
⁵⁵ Department of Human Nutrition, Wageningen University, PO Box 17, Wageningen, 6700 AA, The Netherlands.
⁵⁶ Alan Edwards Centre for Research on Pain, McGill University, Montreal, H3A 0G1, Canada.
⁵⁷ Regional Center for Neurosensory Disorders, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
⁵⁸ Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, 00014, Finland.
⁵⁹ Unit of General Practice, Helsinki University Central Hospital, Helsinki, 00014, Finland.
⁶⁰ Folkhalsan Research Centre, Helsinki, 00250, Finland.
⁶¹ Vasa Central Hospital, Vasa, 65130, Finland.
⁶² National Institute for Health and Welfare, Helsinki, 00271, Finland.
⁶³ Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute for Aging, Bethesda, MD, 20892, USA.
⁶⁴ Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
⁶⁵ Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
⁶⁶ Institute for Integrative Genome Biology, University of California, Riverside, CA, 92521, USA.
⁶⁷ Department of Botany and Plant Sciences, University of California, Riverside, CA, 92521, USA.
⁶⁸ Departments of Medicine and Epidemiology, Boston University School of Medicine and Public Health, Boston, MA, 02118, USA.
⁶⁹ German Center for Diabetes Research (DZD), Neuherberg, Germany.
⁷⁰ CCG Type 2 Diabetes, Helmholtz Zentrum München, Neuherberg, 85764, Germany.
⁷¹ CCG Nutrigenomics and Type 2 Diabetes. Helmholtz Zentrum München, Neuherberg, 85764, Germany.
⁷² National Heart and Lung Institute, Imperial College London, London, SW3 6LY, UK.
⁷³ Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, 28159, Korea.
⁷⁴ MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, Scotland, EH4 2XU, UK.
⁷⁵ Department of Pharmaceutical Sciences, SUNY Binghamton, Binghamton, NY, 13902, USA.
⁷⁶ Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, 17487, Germany.
⁷⁷ Department of Exercise and Nutrition Sciences, George Washington University, Washington, DC, 20052, USA.
⁷⁸ Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC, 20052, USA.
⁷⁹ Division of Biostatistics, School of Public Health, University of California, Berkeley, CA, 94720, USA.
⁸⁰ Division of Rheumatology, Department of Medicine, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 27710, USA.
⁸¹ Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, DK 8000, Denmark.
⁸² Department of Human Genetics, Hannover Medical School, Hannover, 30625, Germany.
⁸³ Hannover Unified Biobank, Hannover Medical School, Hannover, 30625, Germany.
⁸⁴ Department of Medical Sciences, Uppsala University, Uppsala, 75185, Sweden.
⁸⁵ Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
⁸⁶ Institute for Community Medicine, University of Greifswald, Greifswald, 17489, Germany.
⁸⁷ Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SE 405 30, Sweden.
⁸⁸ Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27517, USA.
⁸⁹ Department of Clinical Sciences and Orthopaedics, Lund University, Skåne University Hospital SUS, Malmö, 22362, Sweden.
⁹⁰ Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
⁹¹ The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Copenhagen, 2100, Denmark.
⁹² Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
⁹³ Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, 00029, Finland.
⁹⁴ Endocrinology, Abdominal Center, University of Helsinki and Helsinki University Central Hospital, Helsinki, 00029, Finland.
⁹⁵ Department of Health, National Institute for Health and Welfare, Helsinki, 00271, Finland.
⁹⁶ Minerva Foundation Institute for Medical Research, Helsinki, 00290, Finland.
⁹⁷ Division of Cardiology, Department of Medicine, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 27710, USA.
⁹⁸ Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
⁹⁹ Institute of Behavioural Sciences, University of Helsinki, Helsinki, FI00014, Finland.
¹⁰⁰ University of California San Francisco, San Francisco, CA, 94143, USA.
¹⁰¹ School of Medicine and Pharmacology, University of Western Australia, Perth, 6009, Australia.
¹⁰² Centre for Kidney Research, School of Public Health, University of Sydney, Sydney, 2006, Australia.
¹⁰³ Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, OX3 7BN, UK.
¹⁰⁴ Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC, 27517, USA.
¹⁰⁵ Max Planck Institute for Molecular Genetics, Berlin, 14195, Germany.
¹⁰⁶ Max Planck Institute for Human Development, Berlin, 14195, Germany.
¹⁰⁷ Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
¹⁰⁸ Buck Institute for Research on Aging, Novato, CA, 94945, USA.
¹⁰⁹ Leonard Davis School of Gerontology, University of Southern California, LA, CA, 90089, USA.
¹¹⁰ Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, 21201, USA.
¹¹¹ Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3BX, UK.
¹¹² Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
¹¹³ Oregon Health & Science University, Portland, OR, 97239, USA.
¹¹⁴ Department of Clinical Genetics, Erasmus MC, Rotterdam, 300 CA, The Netherlands.
¹¹⁵ Centre for Medical Systems Biology and Netherlands Consortium on Healthy Aging, Leiden, RC2300, The Netherlands.
¹¹⁶ Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00251, Finland.
¹¹⁷ Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, FI00014, Finland.
¹¹⁸ Human Genetics and Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.
¹¹⁹ Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
¹²⁰ Diabetes and Obesity Research Program, University of Helsinki, Helsinki, FI00014, Finland.
¹²¹ Estonian Genome Center, University of Tartu, Tartu, Estonia.
¹²² Faculty of Medicine, Department of Public Health, University of Split, Split, 21000, Croatia.
¹²³ Department of Endocrinology and Diabetes, Sir Charles Gardiner Hospital, Perth, 6009, Australia.
¹²⁴ Molecular Medicine Centre, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, EH4 2XU, UK.
¹²⁵ Hjelt Institute, University of Helsinki, Helsinki, Finland.
¹²⁶ Department of Medicine, University of California at Davis, Sacramento, CA, 95817, USA.
¹²⁷ Institute for Translational Genomic and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor UCLA Medical Center, Torrance, CA, 90502, USA.
¹²⁸ Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
¹²⁹ Department of Genetics and Genomic Science, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
¹³⁰ Department of Endocrinology and Metabolism, Landspitali, The National University Hospital of Iceland, Reykjavik, 101, Iceland.
¹³¹ Center for Translational Pain Medicine, Department of Anesthiology, Duke University Medical Center, Durham, NC, 27110, USA.
¹³² Geriatric Research and Education Clinical Center (GRECC) - Veterans Administration Medical Center, Baltimore, MD, 21201, USA.
¹³³ Department of Epidemiology and Biostatistics, and the EMGO Institute, VU University Medical Center, Amsterdam, BT1081, The Netherlands.
¹³⁴ Department of Medicine, McMaster University Medical Center, Hamilton, ON, Canada, L8N 3Z5.
¹³⁵ Department of Pathology, Stony Brook School of Medicine, Stony Brook, NY, 11794, USA.
¹³⁶ Department of Neuroscience and Preventive Medicine, Danube-University Krems, Krems, 3500, Austria.
¹³⁷ Diabetes Research Group, King Abdulaziz University, Jeddah, 12589, Saudi Arabia.
¹³⁸ Dasman Diabetes Institute, Dasman, 15462, Kuwait.
¹³⁹ Department of Medicine and Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, CH-1011, Switzerland.
¹⁴⁰ Department of Epidemiology and Environmental Health, University at Buffalo, State University of New York, Buffalo, NY, 14214, USA.
¹⁴¹ Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
¹⁴² Genetics of Complex Traits, University of Exeter Medical School, Exeter, EX1 2LU, UK.
¹⁴³ Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, 81377, Germany.
¹⁴⁴ Institute of Medical Statistics and Epidemiology, Technical University, Munich, 81675, Germany.
¹⁴⁵ Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
¹⁴⁶ NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, SW3 6NP, UK.
¹⁴⁷ Imperial College Healthcare NHS Trust, London, W2 1NY, UK.
¹⁴⁸ Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
¹⁴⁹ Department of Medicine and Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
¹⁵⁰ Departments of Medicine, Epidemiology, and Health Services, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98101, USA.
¹⁵¹ Kaiser Permanente Washington Health Research Institute, Washington, Seattle, WA, 98101, USA.
¹⁵² Medical Genetics, GlaxoSmithKline, Philadelphia, PA, 19112, USA.
¹⁵³ The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
¹⁵⁴ Institute of Child Health and Development, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
¹⁵⁵ The Genetics of Obesity and Related Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
¹⁵⁶ Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
¹⁵⁷ Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, 1311502, Israel.
¹⁵⁸ Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA. kiel@hsl.harvard.edu.
¹⁵⁹ Harvard Medical School, Boston, MA, 02115, USA. kiel@hsl.harvard.edu.
¹⁶⁰ Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA. kiel@hsl.harvard.edu.

PMID: 28724990
PMCID: PMC5517526
DOI: 10.1038/s41467-017-00031-7

Meta-Analysis

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

M Carola Zillikens et al. Nat Commun. 2017.

. 2017 Jul 19;8(1):80.

doi: 10.1038/s41467-017-00031-7.

Authors

Affiliations

¹ Department of Internal Medicine, Erasmus MC, Rotterdam, 3000, The Netherlands.
² Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, 2593, The Netherlands.
³ Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.
⁴ Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.
⁵ Harvard Medical School, Boston, MA, 02115, USA.
⁶ Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, Boston, MA, 02115, USA.
⁷ Program in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
⁸ Broad Institute, Cambridge, MA, 02142, USA.
⁹ Sackler Faculty of Medicine, Department of Anatomy and Anthropology, Tel Aviv University, Tel Aviv, 6997801, Israel.
¹⁰ Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Campus, London, WC2R 2LS, UK.
¹¹ Department of Epidemiology, Erasmus MC, Rotterdam, 3000, The Netherlands.
¹² Department of Medical Genetics, University of Lausanne, Lausanne, 1011, Switzerland.
¹³ Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland.
¹⁴ Centre Hospitalier Universitaire (CHUV), University Institute for Social and Preventive Medicine, Lausanne, 1010, Switzerland.
¹⁵ Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
¹⁶ MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 OQQ, UK.
¹⁷ Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
¹⁸ Icelandic Heart Association, Kopavogur, 201, Iceland.
¹⁹ Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.
²⁰ deCODE Genetics, Reykjavik, 101, Iceland.
²¹ Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SE-405 30, Sweden.
²² Department Epidemiology and Biostatistics, School of Public Health, Imperial College, London, SW7 2AZ, UK.
²³ Cardiology Department, Ealing Hospital NHS Trust, Middlesex, UB1 3HW, UK.
²⁴ Department of Medicine A, University of Greifswald, Greifswald, 17489, Germany.
²⁵ Department of Clinical Sciences, Lund University, Malmö, 22362, Sweden.
²⁶ Department of Orthopedics, Skåne University Hospital, Malmö, S-205 02, Sweden.
²⁷ Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Phoenix, AZ, 85014, USA.
²⁸ Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK.
²⁹ NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 OQQ, UK.
³⁰ Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge Metabolic Research Laboratories, Cambridge, CB2 OQQ, UK.
³¹ Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA.
³² Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Experimental & Integrative Genomics, University of Lübeck, Lübeck, 23562, Germany.
³³ School of Public Health, Faculty of Medicine, Imperial College London, London, W6 8RP, UK.
³⁴ Centre of Oral Health, Department of Prosthetic Dentistry, Gerodontology and Biomaterials, University of Greifswald, Greifswald, 17489, Germany.
³⁵ Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
³⁶ Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, 63110, USA.
³⁷ Division of Biostatistics, Washington University School of Medicine, St Louis, MO, 63110, USA.
³⁸ Department of Surgical Sciences, Uppsala University, Uppsala, 75185, Sweden.
³⁹ Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, EH8 9AG, UK.
⁴⁰ Department of Epidemiology Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
⁴¹ California Pacific Medical Center Research Institute, San Francisco, CA, 94107, USA.
⁴² Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland.
⁴³ Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, 85714, USA.
⁴⁴ Department of Preventive Medicine, Ajou University School of Medicine, Youngtong-Gu, Suwon, 16499, Korea.
⁴⁵ Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 03080, Korea.
⁴⁶ Department of Internal Medicine, Chungbuk National University Hospital, Cheongju Si, Korea.
⁴⁷ Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA, 02139, USA.
⁴⁸ Institute of Human Genetics, MRI, Technische Universität München, Munich, 81675, Germany.
⁴⁹ Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.
⁵⁰ Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, Bethesda, MD, 20892, USA.
⁵¹ Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, MA, 02115, USA.
⁵² Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, 02142, USA.
⁵³ Lipid Clinic at the Interdisciplinary Metabolism Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, 13353, Germany.
⁵⁴ Institute of Medical and Human Genetics, Charité - Universitätsmedizin Berlin, Berlin, 13353, Germany.
⁵⁵ Department of Human Nutrition, Wageningen University, PO Box 17, Wageningen, 6700 AA, The Netherlands.
⁵⁶ Alan Edwards Centre for Research on Pain, McGill University, Montreal, H3A 0G1, Canada.
⁵⁷ Regional Center for Neurosensory Disorders, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
⁵⁸ Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, 00014, Finland.
⁵⁹ Unit of General Practice, Helsinki University Central Hospital, Helsinki, 00014, Finland.
⁶⁰ Folkhalsan Research Centre, Helsinki, 00250, Finland.
⁶¹ Vasa Central Hospital, Vasa, 65130, Finland.
⁶² National Institute for Health and Welfare, Helsinki, 00271, Finland.
⁶³ Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute for Aging, Bethesda, MD, 20892, USA.
⁶⁴ Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
⁶⁵ Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
⁶⁶ Institute for Integrative Genome Biology, University of California, Riverside, CA, 92521, USA.
⁶⁷ Department of Botany and Plant Sciences, University of California, Riverside, CA, 92521, USA.
⁶⁸ Departments of Medicine and Epidemiology, Boston University School of Medicine and Public Health, Boston, MA, 02118, USA.
⁶⁹ German Center for Diabetes Research (DZD), Neuherberg, Germany.
⁷⁰ CCG Type 2 Diabetes, Helmholtz Zentrum München, Neuherberg, 85764, Germany.
⁷¹ CCG Nutrigenomics and Type 2 Diabetes. Helmholtz Zentrum München, Neuherberg, 85764, Germany.
⁷² National Heart and Lung Institute, Imperial College London, London, SW3 6LY, UK.
⁷³ Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, 28159, Korea.
⁷⁴ MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, Scotland, EH4 2XU, UK.
⁷⁵ Department of Pharmaceutical Sciences, SUNY Binghamton, Binghamton, NY, 13902, USA.
⁷⁶ Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, 17487, Germany.
⁷⁷ Department of Exercise and Nutrition Sciences, George Washington University, Washington, DC, 20052, USA.
⁷⁸ Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC, 20052, USA.
⁷⁹ Division of Biostatistics, School of Public Health, University of California, Berkeley, CA, 94720, USA.
⁸⁰ Division of Rheumatology, Department of Medicine, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 27710, USA.
⁸¹ Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, DK 8000, Denmark.
⁸² Department of Human Genetics, Hannover Medical School, Hannover, 30625, Germany.
⁸³ Hannover Unified Biobank, Hannover Medical School, Hannover, 30625, Germany.
⁸⁴ Department of Medical Sciences, Uppsala University, Uppsala, 75185, Sweden.
⁸⁵ Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
⁸⁶ Institute for Community Medicine, University of Greifswald, Greifswald, 17489, Germany.
⁸⁷ Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SE 405 30, Sweden.
⁸⁸ Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27517, USA.
⁸⁹ Department of Clinical Sciences and Orthopaedics, Lund University, Skåne University Hospital SUS, Malmö, 22362, Sweden.
⁹⁰ Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
⁹¹ The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Copenhagen, 2100, Denmark.
⁹² Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
⁹³ Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, 00029, Finland.
⁹⁴ Endocrinology, Abdominal Center, University of Helsinki and Helsinki University Central Hospital, Helsinki, 00029, Finland.
⁹⁵ Department of Health, National Institute for Health and Welfare, Helsinki, 00271, Finland.
⁹⁶ Minerva Foundation Institute for Medical Research, Helsinki, 00290, Finland.
⁹⁷ Division of Cardiology, Department of Medicine, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 27710, USA.
⁹⁸ Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
⁹⁹ Institute of Behavioural Sciences, University of Helsinki, Helsinki, FI00014, Finland.
¹⁰⁰ University of California San Francisco, San Francisco, CA, 94143, USA.
¹⁰¹ School of Medicine and Pharmacology, University of Western Australia, Perth, 6009, Australia.
¹⁰² Centre for Kidney Research, School of Public Health, University of Sydney, Sydney, 2006, Australia.
¹⁰³ Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, OX3 7BN, UK.
¹⁰⁴ Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC, 27517, USA.
¹⁰⁵ Max Planck Institute for Molecular Genetics, Berlin, 14195, Germany.
¹⁰⁶ Max Planck Institute for Human Development, Berlin, 14195, Germany.
¹⁰⁷ Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
¹⁰⁸ Buck Institute for Research on Aging, Novato, CA, 94945, USA.
¹⁰⁹ Leonard Davis School of Gerontology, University of Southern California, LA, CA, 90089, USA.
¹¹⁰ Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, 21201, USA.
¹¹¹ Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3BX, UK.
¹¹² Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
¹¹³ Oregon Health & Science University, Portland, OR, 97239, USA.
¹¹⁴ Department of Clinical Genetics, Erasmus MC, Rotterdam, 300 CA, The Netherlands.
¹¹⁵ Centre for Medical Systems Biology and Netherlands Consortium on Healthy Aging, Leiden, RC2300, The Netherlands.
¹¹⁶ Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00251, Finland.
¹¹⁷ Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, FI00014, Finland.
¹¹⁸ Human Genetics and Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.
¹¹⁹ Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
¹²⁰ Diabetes and Obesity Research Program, University of Helsinki, Helsinki, FI00014, Finland.
¹²¹ Estonian Genome Center, University of Tartu, Tartu, Estonia.
¹²² Faculty of Medicine, Department of Public Health, University of Split, Split, 21000, Croatia.
¹²³ Department of Endocrinology and Diabetes, Sir Charles Gardiner Hospital, Perth, 6009, Australia.
¹²⁴ Molecular Medicine Centre, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, EH4 2XU, UK.
¹²⁵ Hjelt Institute, University of Helsinki, Helsinki, Finland.
¹²⁶ Department of Medicine, University of California at Davis, Sacramento, CA, 95817, USA.
¹²⁷ Institute for Translational Genomic and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor UCLA Medical Center, Torrance, CA, 90502, USA.
¹²⁸ Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
¹²⁹ Department of Genetics and Genomic Science, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
¹³⁰ Department of Endocrinology and Metabolism, Landspitali, The National University Hospital of Iceland, Reykjavik, 101, Iceland.
¹³¹ Center for Translational Pain Medicine, Department of Anesthiology, Duke University Medical Center, Durham, NC, 27110, USA.
¹³² Geriatric Research and Education Clinical Center (GRECC) - Veterans Administration Medical Center, Baltimore, MD, 21201, USA.
¹³³ Department of Epidemiology and Biostatistics, and the EMGO Institute, VU University Medical Center, Amsterdam, BT1081, The Netherlands.
¹³⁴ Department of Medicine, McMaster University Medical Center, Hamilton, ON, Canada, L8N 3Z5.
¹³⁵ Department of Pathology, Stony Brook School of Medicine, Stony Brook, NY, 11794, USA.
¹³⁶ Department of Neuroscience and Preventive Medicine, Danube-University Krems, Krems, 3500, Austria.
¹³⁷ Diabetes Research Group, King Abdulaziz University, Jeddah, 12589, Saudi Arabia.
¹³⁸ Dasman Diabetes Institute, Dasman, 15462, Kuwait.
¹³⁹ Department of Medicine and Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, CH-1011, Switzerland.
¹⁴⁰ Department of Epidemiology and Environmental Health, University at Buffalo, State University of New York, Buffalo, NY, 14214, USA.
¹⁴¹ Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
¹⁴² Genetics of Complex Traits, University of Exeter Medical School, Exeter, EX1 2LU, UK.
¹⁴³ Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, 81377, Germany.
¹⁴⁴ Institute of Medical Statistics and Epidemiology, Technical University, Munich, 81675, Germany.
¹⁴⁵ Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
¹⁴⁶ NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, SW3 6NP, UK.
¹⁴⁷ Imperial College Healthcare NHS Trust, London, W2 1NY, UK.
¹⁴⁸ Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
¹⁴⁹ Department of Medicine and Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
¹⁵⁰ Departments of Medicine, Epidemiology, and Health Services, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98101, USA.
¹⁵¹ Kaiser Permanente Washington Health Research Institute, Washington, Seattle, WA, 98101, USA.
¹⁵² Medical Genetics, GlaxoSmithKline, Philadelphia, PA, 19112, USA.
¹⁵³ The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
¹⁵⁴ Institute of Child Health and Development, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
¹⁵⁵ The Genetics of Obesity and Related Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
¹⁵⁶ Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
¹⁵⁷ Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, 1311502, Israel.
¹⁵⁸ Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA. kiel@hsl.harvard.edu.
¹⁵⁹ Harvard Medical School, Boston, MA, 02115, USA. kiel@hsl.harvard.edu.
¹⁶⁰ Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA. kiel@hsl.harvard.edu.

PMID: 28724990
PMCID: PMC5517526
DOI: 10.1038/s41467-017-00031-7

Erratum in

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
Zillikens MC, Demissie S, Hsu YH, Yerges-Armstrong LM, Chou WC, Stolk L, Livshits G, Broer L, Johnson T, Koller DL, Kutalik Z, Luan J, Malkin I, Ried JS, Smith AV, Thorleifsson G, Vandenput L, Hua Zhao J, Zhang W, Aghdassi A, Åkesson K, Amin N, Baier LJ, Barroso I, Bennett DA, Bertram L, Biffar R, Bochud M, Boehnke M, Borecki IB, Buchman AS, Byberg L, Campbell H, Campos Obanda N, Cauley JA, Cawthon PM, Cederberg H, Chen Z, Cho NH, Jin Choi H, Claussnitzer M, Collins F, Cummings SR, De Jager PL, Demuth I, Dhonukshe-Rutten RAM, Diatchenko L, Eiriksdottir G, Enneman AW, Erdos M, Eriksson JG, Eriksson J, Estrada K, Evans DS, Feitosa MF, Fu M, Garcia M, Gieger C, Girke T, Glazer NL, Grallert H, Grewal J, Han BG, Hanson RL, Hayward C, Hofman A, Hoffman EP, Homuth G, Hsueh WC, Hubal MJ, Hubbard A, Huffman KM, Husted LB, Illig T, Ingelsson E, Ittermann T, Jansson JO, Jordan JM, Jula A, Karlsson M, Khaw KT, Kilpeläinen TO, Klopp N, Kloth JSL, Koistinen HA, Kraus WE, Kritchevsky S, Kuulasmaa T, Kuusisto J, Laakso M, Lahti J, Lang T, Langdahl BL, Launer LJ, Lee JY, Lerch MM, Lewis JR, Lind L, Lindgren C, Liu Y, Liu T, Liu Y, Ljunggren Ö, Lorentzon M, Luben RN, Maixner W, McGuigan FE, Medina-… See abstract for full author list ➔ Zillikens MC, et al. Nat Commun. 2017 Nov 7;8(1):1414. doi: 10.1038/s41467-017-01008-2. Nat Commun. 2017. PMID: 29116125 Free PMC article.

Abstract

Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 × 10^-8) or suggestively genome wide (p < 2.3 × 10^-6). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.Lean body mass is a highly heritable trait and is associated with various health conditions. Here, Kiel and colleagues perform a meta-analysis of genome-wide association studies for whole body lean body mass and find five novel genetic loci to be significantly associated.

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Conflict of interest statement

The authors declare no competing financial interests.

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Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

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Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

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Erratum in

Abstract

Conflict of interest statement

References

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