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. 2017:1632:65-74.
doi: 10.1007/978-1-4939-7138-1_4.

Rolling Circle Transcription for the Self-Assembly of Multimeric RNAi Structures and Its Applications in Nanomedicine

Mihue Jang  1 , Hyung Jun Ahn  2
Affiliations

Rolling Circle Transcription for the Self-Assembly of Multimeric RNAi Structures and Its Applications in Nanomedicine

Mihue Jang et al. Methods Mol Biol. 2017.

Abstract

The enzymatic process of rolling circle transcription (RCT) enables self-assembly of multimeric RNAi structures from a circular DNA template. The self-assembled RNAi structures can be manipulated easily by simple base pairing rules with short DNA fragments for constructing multifunctional nanoparticles in the field of nanomedicine. Here we describe the method to generate multifunctional RNAi nanoparticles applicable in nanomedicine.

Keywords: Base pairing; DNA–RNA hybrids; Delivery of siRNA; Multimeric RNAi structures; Rolling circle transcription.

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