Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Dec;18(1):72.
doi: 10.1186/s10194-017-0782-6. Epub 2017 Jul 20.

Functional connectivity and cognitive impairment in migraine with and without aura

Affiliations

Functional connectivity and cognitive impairment in migraine with and without aura

Viviana Lo Buono et al. J Headache Pain. 2017 Dec.

Abstract

Background: Several fMRI studies in migraine assessed resting state functional connectivity in different networks suggesting that this neurological condition was associated with brain functional alteration. The aim of present study was to explore the association between cognitive functions and cerebral functional connectivity, in default mode network, in migraine patients without and with aura, during interictal episodic attack.

Methods: Twenty-eight migraine patients (14 without and 14 with aura) and 14 matched normal controls, were consecutively recruited. A battery of standardized neuropsychological test was administered to evaluate cognitive functions and all subjects underwent a resting state with high field fMRI examination.

Results: Migraine patients did not show abnormalities in neuropsychological evaluation, while, we found a specific alteration in cortical network, if we compared migraine with and without aura. We observed, in migraine with aura, an increased connectivity in left angular gyrus, left supramarginal gyrus, right precentral gyrus, right postcentral gyrus, right insular cortex.

Conclusion: Our findings showed in migraine patients an alteration in functional connectivity architecture. We think that our results could be useful to better understand migraine pathogenesis.

Keywords: Cognitive functions; Functional connectivity, default mode network; Migraine.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

Participants provided written informed consent. The study protocol was approved by the Local Ethics Committee according to Declaration of Helsinki.

Competing interests

The authors have no competing interests to report.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Functional connectivity average DMN of groups: a. MA > MO group; b. MA > HC; c. MO > HC group. MA patients showed increased functional connectivity compared MO (blue areas, p values are color coded from 0.05 FWE corrected (dark blue) to <0.0001 FWE corrected (light blue), full list of structures in Table 2). Axial images are overlaid on transverse slices of MNI-152 standard anatomical image. The left side of the brain corresponds to the right hemisphere and vice versa. Z-coordinates of each slice in the MNI-152 standard space are given

References

    1. Schwedt TJ. Multisensory integration in migraine. Curr Opin Neurol. 2013;26(3):248. doi: 10.1097/WCO.0b013e328360edb1. - DOI - PMC - PubMed
    1. Tessitore A, Russo A, Giordano A, Conte F, Corbo D, De Stefano M, Cirillo S, Cirillo M, Esposito F, Tedeschi G. Disrupted default mode network connectivity in migraine without aura. J Headache Pain. 2013;14:89. doi: 10.1186/1129-2377-14-89. - DOI - PMC - PubMed
    1. Rasmussen BK, Olesen J. Migraine with aura and migraine without aura: an epidemiological study. Cephalalgia. 1992;12(4):221–228. doi: 10.1046/j.1468-2982.1992.1204221.x. - DOI - PubMed
    1. Corallo F, De Cola MC, Lo Buono V, Grugno R, Pintabona G, Presti L, et al. Assessment of anxiety, depressive disorders and pain intensity in migraine and tension headache patients. Acta Med Austriaca. 2015;31:615.
    1. Santangelo G, Russo A, Trojano L, Falco F, Marcuccio L, Siciliano M, Conte F, Garramone TA, Tedeschi G. Cognitive dysfunctions and psychological symptoms in migraine without aura: a cross-sectional study. J Headache Pain. 2016;17(1):76. doi: 10.1186/s10194-016-0667-0. - DOI - PMC - PubMed

MeSH terms