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. 2018 Mar;50(2).
doi: 10.1111/and.12855. Epub 2017 Jul 21.

Study of the prevalence of 5 HT-2C receptor gene polymorphisms in Egyptian patients with lifelong premature ejaculation

M F Roaiah  1 , Y I Elkhayat  1 , L A Rashed  2 , S F GamalEl Din  1 , A M El Guindi  1 , M A Abd El Salam  1
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Study of the prevalence of 5 HT-2C receptor gene polymorphisms in Egyptian patients with lifelong premature ejaculation

M F Roaiah et al. Andrologia. 2018 Mar.

Abstract

We investigated the prevalence of 5HT2C receptor gene polymorphisms in Egyptian patients with lifelong premature ejaculation. A total of 350 participants were enrolled in a prospective study. Two hundred and forty-five cases with lifelong premature ejaculation joined this study, in addition to 105 controls. We instructed the partners of the cases to measure the IELT of the first intercourse only using a stopwatch for 1 month. Genotyping was carried out at the end of the study. The results showed that the majority of the patients and controls were Cys/Cys. A highly significant statistical association was found between the studied gene polymorphisms and IELT among cases (p-values = .009). The study emphasised the potential role of 5HT2C receptor gene polymorphisms in patients with lifelong premature ejaculation.

Keywords: 5HT2C receptor gene polymorphism; intravaginal ejaculation latency time; lifelong premature ejaculation.

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