Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017;27(4):225-237.
doi: 10.18176/jiaci.0177.

Oral Immunotherapy for Food Allergy: A Spanish Guideline. Immunotherapy Egg and Milk Spanish Guide (ITEMS Guide). Part I: Cow Milk and Egg Oral Immunotherapy: Introduction, Methodology, Rationale, Current State, Indications, Contraindications, and Oral Immunotherapy Build-up Phase

A Martorell  1 , E Alonso  2 , L Echeverría  3 , C Escudero  4 , R García-Rodríguez  5 , C Blasco  6 , J Bone  7 , J Borja-Segade  5 , T Bracamonte  3 , A Claver  8 , J L Corzo  9 , B De la Hoz  10 , R Del Olmo  11 , O Dominguez  12 , V Fuentes-Aparicio  13 , I Guallar  7 , H Larramona  14 , F Martín-Muñoz  15 , V Matheu  16 , A Michavila  17 , I Ojeda  18 , P Ojeda  18 , M Piquer  12 , P Poza  16 , M Reche  19 , P Rodríguez Del Río  4 , M Rodríguez  20 , F Ruano  21 , S Sánchez-García  4 , S Terrados  22 , L Valdesoiro, M Vazquez-Ortiz  23 ; Expert panel selected from members of the Spanish Society of Pediatric Allergology, Asthma and Clinical Immunology (SEICAP) and the Spanish Society of Allergology and Clinical Immunology (SEAIC)
Affiliations
Free article
Review

Oral Immunotherapy for Food Allergy: A Spanish Guideline. Immunotherapy Egg and Milk Spanish Guide (ITEMS Guide). Part I: Cow Milk and Egg Oral Immunotherapy: Introduction, Methodology, Rationale, Current State, Indications, Contraindications, and Oral Immunotherapy Build-up Phase

A Martorell et al. J Investig Allergol Clin Immunol. 2017.
Free article

Abstract

Background and objective: Cow milk and egg are the most frequent causes of food allergy in the first years of life. Oral immunotherapy (OIT) has been investigated as an alternative to avoidance diets. No clinical practice guidelines on the management of OIT with milk and egg are currently available. Objectives: To develop clinical guidelines for OIT based on available scientific evidence and the opinions of experts.

Methods: A review was made of studies published between 1984 and June 2016, doctoral theses published in Spain, summaries of communications at scientific meetings (SEAIC, SEICAP, EAACI, and AAAAI), and the consensus of opinion established by a group of experts from the scientific societies SEICAP and SEAIC.

Results: Recommendations were established regarding the indications, requirements and practical aspects of the different phases of OIT, as well as special protocols for patients at high risk of adverse reactions.

Conclusions: Clinical practice guidelines based on the consensus reached between Spanish experts are presented for the management of OIT with milk and egg.

Keywords: Desensitization; Egg allergy; Guide; Milk allergy; Omalizumab; Oral immunotherapy; Specific oral tolerance induction; Sublingual immunotherapy.

PubMed Disclaimer

LinkOut - more resources