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Review
. 2017 Jul 20;67(2):168-179.
doi: 10.1016/j.molcel.2017.06.016.

Unique Roles of the Non-identical MCM Subunits in DNA Replication Licensing

Yuanliang Zhai  1 , Ningning Li  2 , Hanlun Jiang  3 , Xuhui Huang  3 , Ning Gao  4 , Bik Kwoon Tye  5
Affiliations
Free article
Review

Unique Roles of the Non-identical MCM Subunits in DNA Replication Licensing

Yuanliang Zhai et al. Mol Cell. .
Free article

Abstract

A family of six homologous subunits, Mcm2, -3, -4, -5, -6, and -7, each with its own unique features, forms the catalytic core of the eukaryotic replicative helicase. The necessity of six similar but non-identical subunits has been a mystery since its initial discovery. Recent cryo-EM structures of the Mcm2-7 (MCM) double hexamer, its precursors, and the origin recognition complex (ORC)-Cdc6-Cdt1-Mcm2-7 (OCCM) intermediate showed that each of these subunits plays a distinct role in orchestrating the assembly of the pre-replication complex (pre-RC) by ORC-Cdc6 and Cdt1.

Keywords: Acrobat Model for pre-RC assembly; DNA replication initiation; Mcm2–7; ORC-Cdc6-Cdt1-MCM; cryo-EM structures.

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