Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jul 21;18(1):43.
doi: 10.1186/s12889-017-4587-y.

Alcohol use disorders and associated chronic disease - a national retrospective cohort study from France

Michaël Schwarzinger  1 , Sophie Pascale Thiébaut  1 , Sylvain Baillot  1 , Vincent Mallet  2   3 , Jürgen Rehm  4   5   6   7   8   9
Affiliations

Alcohol use disorders and associated chronic disease - a national retrospective cohort study from France

Michaël Schwarzinger et al. BMC Public Health. .

Erratum in

  • Erratum to: BMC Public Health, Vol. 18.
    [No authors listed] [No authors listed] BMC Public Health. 2017 Sep 22;17(1):736. doi: 10.1186/s12889-017-4709-6. BMC Public Health. 2017. PMID: 28938882 Free PMC article. No abstract available.

Abstract

Background: Evidence on diseases caused by or associated with alcohol use disorders (AUDs) has been based on two meta-analyses including rather dated studies. The objective of this contribution was to estimate the risks of all-cause mortality and alcohol-attributable disease categories depending on a diagnosis of AUDs in a national sample for France.

Methods: In a national retrospective cohort study on all inpatient acute and rehabilitation care patients in Metropolitan France 2008-2012 (N = 26,356,361), AUDs and other disease categories were identified from all discharge diagnoses according to standard definitions, and we relied on in-hospital death for mortality (57.4% of all deaths).

Results: 704,803 (2.7%) patients identified with AUDs had a threefold higher risk of death (HR = 2.98; 95% CI: 2.96-3.00) and died on average 12.2 years younger (men: 10.4, 95% CI: 10.3-10.5; women: 13.7, 95% CI: 13.6-13.9). AUDs were associated with significantly higher risks of hospital admission for all alcohol-attributable disease categories: digestive diseases, cancers (exception: breast cancer), cardiovascular diseases, dementia, infectious diseases, and injuries. Elevated risks were highest for liver diseases that were associated with about two-third of deaths in patients with AUDs (men: 64.3%; women: 71.1%).

Conclusions: AUDs were associated with marked premature mortality and higher risks of alcohol-attributable disease categories. Our results support the urgent need of measures to reduce the burden of AUDs.

Keywords: Alcohol use disorders; Burden of disease; Mortality; Non-communicable disease; Risk factor.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

The study was approved by the French National Commission for Data Protection (CNIL DE-2013-068). The requirement for informed consent was waived because the study used de-identified data.

Consent for publication

Not applicable.

Competing interests

All authors have completed the ICMJE Competing Interest form and declare that: MS, SPT, and SB have support from THEN (Translational Health Economics Network) for the submitted work; VM has no financial or non-financial interests that may be relevant to the submitted work; JR reports grants, personal fees and past board membership (Nalmefene) for Lundbeck, outside and unrelated to the submitted work. No other relationships or activities that could appear to have influenced the submitted work are reported.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Instantaneous risk of death of people with alcoholic use disorders over lifetime (French National Hospital Discharge database 2008–2012)
See this image and copyright information in PMC

References

    1. World Health Organization . Global status report on alcohol and health. Geneva, Switzerland: World Health Organization; 2014.
    1. GBD 2015 Risk Factors Collaborators Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2016;388:1659–1724. doi: 10.1016/S0140-6736(16)31679-8. - DOI - PMC - PubMed
    1. World Health Organization . ICD-10 classification of mental and behavioural disorders: with glossary and diagnostic criteria for research. New York, N.Y: Churchill Livingstone; 1994.
    1. Rehm J, Shield KD, Gmel G, Rehm MX, Frick U. Modeling the impact of alcohol dependence on mortality burden and the effect of available treatment interventions in the European Union. Eur Neuropsychopharmacol. 2013;23:89–97. doi: 10.1016/j.euroneuro.2012.08.001. - DOI - PubMed
    1. Rehm J, Dawson D, Frick U, Gmel G, Roerecke M, Shield KD, et al. Burden of disease associated with alcohol use disorders in the United States Alcohol. Clin Exp Res. 2014;38:1068–1077. doi: 10.1111/acer.12331. - DOI - PMC - PubMed

MeSH terms