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. 1986 Jul 26;2(8500):184-6.
doi: 10.1016/s0140-6736(86)92487-6.

Diagnosis of giardiasis by specific IgM antibody enzyme-linked immunosorbent assay

A K Goka, D D Rolston, V I Mathan, M J Farthing

Diagnosis of giardiasis by specific IgM antibody enzyme-linked immunosorbent assay

A K Goka et al. Lancet. .

Abstract

An enzyme-linked immunosorbent assay (ELISA) was used to detect serum IgM and IgG antibodies against Giardia in fifty-two patients with diarrhoea from the United Kingdom and south India. Serum anti-Giardia IgM responses occurred in patients with giardiasis; in two of three patients studied longitudinally IgM levels had fallen to normal 2-3 weeks after treatment. At serum dilutions of 1/200 to 1/400 there was almost complete separation of ELISA readings between patients with Giardia and Giardia-free controls; the sensitivity and specificity of the ELISA were both 96%. Serum anti-Giardia IgG was detected in patients and controls but was unable to distinguish current from previous infection.

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Comment in

  • ELISA for anti-giardia IgM.
    Gandhi BM, Buch P, Sharma MP, Irshad M, Samantray SC. Gandhi BM, et al. Lancet. 1989 Sep 16;2(8664):685. doi: 10.1016/s0140-6736(89)90935-5. Lancet. 1989. PMID: 2570940 No abstract available.

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