Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Aug;40(8):885-893.
doi: 10.1007/s12272-017-0933-y. Epub 2017 Jul 22.

Pneumonia and Streptococcus pneumoniae vaccine

Gyu-Lee Kim  1 , Seung-Han Seon  1 , Dong-Kwon Rhee  2
Affiliations
Review

Pneumonia and Streptococcus pneumoniae vaccine

Gyu-Lee Kim et al. Arch Pharm Res. 2017 Aug.

Abstract

Pneumonia is an inflammatory disease of the lung, responsible for high morbidity and mortality worldwide. It is caused by bacteria, viruses, fungi, or other microorganisms. Streptococcus pneumoniae, a gram-positive bacterium with over 90 serotypes, is the most common causative agent. Moreover, comorbid factors including heart failure, renal disease, and pulmonary disease could increase the risk of pneumococcal pneumonia. Since the advent of the pneumococcal vaccine in the 1980s, the incidence of pneumonia has decreased significantly. However, current vaccines confer only limited protection against serotypes included in the vaccine. Thus, to overcome this limitation, new types of pneumococcal vaccines have been sought and under clinical trials. In this review, we discuss pneumonia and summarize the various types of pneumococcal vaccines in progress.

Keywords: Pneumococcal vaccine; Pneumonia; Streptococcus pneumoniae.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Andre G, Converso TR, Politano WR, Ferraz LF, Ribeiro ML, Leite LC, Darrieux M. Role of Streptococcus pneumoniae proteins in evasion of complement-mediated immunity. Front Microbiol. 2017;8:224. doi: 10.3389/fmicb.2017.00224. - DOI - PMC - PubMed
    1. Bewick T, Sheppard C, Greenwood S, Slack M, Trotter C, George R, Lim WS. Serotype prevalence in adults hospitalised with pneumococcal non-invasive community-acquired pneumonia. Thorax. 2012;67:540–545. doi: 10.1136/thoraxjnl-2011-201092. - DOI - PubMed
    1. Black RE, Cousens S, Johnson HL, Lawn JE, Rudan I, Bassani DG, Jha P, Campbell H, Walker CF, Cibulskis R, Eisele T, Liu L, Mathers C. Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet. 2010;375:1969–1987. doi: 10.1016/S0140-6736(10)60549-1. - DOI - PubMed
    1. Bogaert D, De Groot R, Hermans PW. Streptococcus pneumoniae colonisation: the key to pneumococcal disease. Lancet Infect Dis. 2004;4:144–154. doi: 10.1016/S1473-3099(04)00938-7. - DOI - PubMed
    1. Briles DE, King JD, Gray MA, Mcdaniel LS, Swiatlo E, Benton KA. PspA, a protection-eliciting pneumococcal protein: immunogenicity of isolated native PspA in mice. Vaccine. 1996;14:858–867. doi: 10.1016/0264-410X(96)82948-3. - DOI - PubMed

MeSH terms

Substances

LinkOut - more resources