Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jul 6:15:84-91.
doi: 10.1016/j.btre.2017.07.002. eCollection 2017 Sep.

Synthesis and characterization of bacterial cellulose and gelatin-based hydrogel composites for drug-delivery systems

W Treesuppharat  1 , P Rojanapanthu  1 , C Siangsanoh  2 , H Manuspiya  3 , S Ummartyotin  2
Affiliations

Synthesis and characterization of bacterial cellulose and gelatin-based hydrogel composites for drug-delivery systems

W Treesuppharat et al. Biotechnol Rep (Amst). .

Abstract

Bacterial cellulose and gelatin were successfully used to develop a hydrogel composite material. Hydrogel was synthesized by copolymerization between bacterial cellulose and gelatin. Scanning electron microscopy (SEM) images showed that the bacterial cellulose chain was uniform in size and shape. Glutaraldehyde was employed as a crosslinking agent. H-bonds were formed via the reaction between the amine and hydroxyl groups, which were the functional groups of the gelatin and bacterial cellulose, respectively. The hydrogel composite presented excellent properties in terms of its thermal stability, chemical resistance, and mechanical properties. Moreover, the swelling ratio of the hydrogel network, in water, was estimated to be 400-600%. Importantly, the hydrogel composite developed during this study is considered a good candidate for drug-delivery systems.

Keywords: Bacterial cellulose; Drug delivery system; Gelatin; Hydrogel.

PubMed Disclaimer

Figures

None
Graphical abstract
Fig. 1
Fig. 1
Chemical reaction between bacterial cellulose and gelatin with glutaraldehyde.
Fig. 2
Fig. 2
Photograph of bacterial cellulose-based hydrogel composite (a) Original form, (b) Stretchable form, (c) Reformable form.
Fig. 3
Fig. 3
FTIR spectra of the gelatin and bacterial cellulose hydrogel composites (a) neat gelatin; and with gelatin-to-bacterial cellulose ratios of (b) 25:1, (c) 50:1, (d) 100:1, (e) 200:1, (f) 300:1, (g) 400:1.
Fig. 4
Fig. 4
Morphological properties of gelatin and bacterial cellulose hydrogel composites (a) neat gelatin; and with gelatin-to-bacterial cellulose ratios of (b) 25:1, (c) 50:1, (d) 100:1, (e) 200:1, (f) 300:1, (g) 400:1.
Fig. 5
Fig. 5
Topological properties of gelatin and bacterial cellulose hydrogel composite; (a) neat gelatin; and with gelatin-to-bacterial cellulose ratios of (b) 25:1, (c) 50:1, (d) 100:1, (e) 200:1, (f) 300:1, (g) 400:1.
Fig. 6
Fig. 6
Thermal degradation behavior of the gelatin and bacterial cellulose hydrogel composites.
Fig. 7
Fig. 7
Differential scanning calorimetry results obtained for the gelatin and bacterial cellulose hydrogel composites.
Fig. 8
Fig. 8
Swelling ratios of gelatin and bacterial cellulose hydrogel composites.
Fig. 9
Fig. 9
Drug release profiles of the neat gelatin hydrogel, and bacterial cellulose and gelatin-based hydrogel composite (with a gelatin-to-bacterial cellulose ratio of 200:1) in deionized water at 37 °C.
See this image and copyright information in PMC

References

    1. Gyles D.A., et al. A review of the designs and prominent biomedical advances of natural and synthetic hydrogel formulations. Eur. Polym. J. 2017;88:373–392.
    1. Kamoun E.A., Kenawy E.-R.S., Chen X. A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings. J. Adv. Res. 2017;8(3):217–233. - PMC - PubMed
    1. Fan M., et al. Covalent and injectable chitosan-chondroitin sulfate hydrogels embedded with chitosan microspheres for drug delivery and tissue engineering. Mater. Sci. Eng.: C. 2017;71:67–74. - PubMed
    1. Singh B., Sharma V. Crosslinking of poly(vinylpyrrolidone)/acrylic acid with tragacanth gum for hydrogels formation for use in drug delivery applications. Carbohydr. Polym. 2017;157:185–195. - PubMed
    1. Xu X., et al. Construction and characterization of a pure protein hydrogel for drug delivery application. Int. J. Biol. Macromol. 2017;95:294–298. - PubMed

LinkOut - more resources