Cadmium Handling, Toxicity and Molecular Targets Involved during Pregnancy: Lessons from Experimental Models

Abstract

Even decades after the discovery of Cadmium (Cd) toxicity, research on this heavy metal is still a hot topic in scientific literature: as we wrote this review, more than 1440 scientific articles had been published and listed by the PubMed.gov website during 2017. Cadmium is one of the most common and harmful heavy metals present in our environment. Since pregnancy is a very particular physiological condition that could impact and modify essential pathways involved in the handling of Cd, the prenatal life is a critical stage for exposure to this non-essential element. To give the reader an overview of the possible mechanisms involved in the multiple organ toxic effects in fetuses after the exposure to Cd during pregnancy, we decided to compile some of the most relevant experimental studies performed in experimental models and to summarize the advances in this field such as the Cd distribution and the factors that could alter it (diet, binding-proteins and membrane transporters), the Cd-induced toxicity in dams (preeclampsia, fertility, kidney injury, alteration in essential element homeostasis and bone mineralization), in placenta and in fetus (teratogenicity, central nervous system, liver and kidney).

Keywords: cadmium; fetus; multiple organs toxicity; placenta; pregnancy.

Figure 1

General scheme of the toxic effects of Cadmium (Cd) exposure in dam, placenta and fetus. MT: Metallothionein; LWMP: Low Molecular Weight Proteins; RME: Receptor-Mediated Endocytosis (e.g., Megalin or 24p3 Receptor); TRPV6: Transient Receptor Potential Cation Channel Subfamily V Member 6; DMT1: Divalent Metal Transporter-1; ZIP-14: Zrt/Irt-like Protein 14; ZnT2: Zinc Transporter 2.