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Comment
. 2018 Mar;15(3):193-195.
doi: 10.1038/cmi.2017.61. Epub 2017 Jul 24.

The innate immune receptor NLRP12 maintains intestinal homeostasis by regulating microbiome diversity

Jenny Moi-Fong Lau  1 , Yvonne Dombrowski  1
Affiliations
Comment

The innate immune receptor NLRP12 maintains intestinal homeostasis by regulating microbiome diversity

Jenny Moi-Fong Lau et al. Cell Mol Immunol. 2018 Mar.
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
NLRP12 regulates microbial diversity and maintains intestinal homeostasis. (a) Hematopoietic NLRP12 maintains intestinal homeostasis by promoting microbial diversity in favor of beneficial Lachnospiraceae, Bacteroidales and Clostridiales and by regulating immunological anergy of intestinal macrophages and dendritic cells. (b) NLRP12 deficiency leads to dysbiosis, a shift in the microbiota towards colitogenic Erysipelotrichaceae, supported by the release of antimicrobial peptides. The associated dysregulated inflammatory reaction mediated by both the hematopoietic and non-hematopoietic compartment is characterized by the release of proinflammatory cytokines such as TNF and IL-6 and exacerbated immune signaling via NF-κB, ERK and STAT pathways. (c) Inoculation of Lachnospiraceae in NLRP12-deficient animals alleviates inflammation by restoring the diversity of the microbiome similar to that of wild-type mice. NLR, nucleotide-binding-domain leucine-rich-repeat receptors; IL, interleukin; TNF, tumor necrosis factor.
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