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Comment
. 2018 Feb;15(2):96-98.
doi: 10.1038/cmi.2017.66. Epub 2017 Jul 24.

Clonal expansion shapes the human Vδ1T cell receptor repertoire

Serena Meraviglia  1 , Francesco Dieli  1
Affiliations
Comment

Clonal expansion shapes the human Vδ1T cell receptor repertoire

Serena Meraviglia et al. Cell Mol Immunol. 2018 Feb.
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The neonatal (cord blood) TCR Vδ1 repertoire is extremely unfocused and private. In most adult individuals, the Vδ1+ TCR repertoire is strongly focused, with up to 50% of the repertoire comprising the 10 most abundant TCRγ and TCRδ1 clonotypes. Moreover, the Vδ1 TCR repertoire was overwhelmingly private, with different TCR clonotypes present in each individual. The nature of the forces governing the peripheral clonal selection of the human Vδ1 TCR repertoire and the role of CMV remains to be determined.
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References

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