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. 2017 Aug 18;82(16):8703-8709.
doi: 10.1021/acs.joc.7b00732. Epub 2017 Aug 1.

t-BuOK-Mediated Oxidative Dehydrogenative C(sp3)-H Arylation of 2-Alkylazaarenes with Nitroarenes

Shuai-Shuai Li  1 , Shiheng Fu  1 , Liang Wang  1 , Lubin Xu  1 , Jian Xiao  1
Affiliations

t-BuOK-Mediated Oxidative Dehydrogenative C(sp3)-H Arylation of 2-Alkylazaarenes with Nitroarenes

Shuai-Shuai Li et al. J Org Chem. .

Abstract

The first transition-metal free and regioselective C(sp3)-H arylation of 2-alkylazaarenes with nitroarenes has been achieved via t-BuOK-mediated dehydrogenative C(sp3)-C(sp2) coupling. This reaction provides an efficient access to the biologically important and synthetically useful 2-benzyl-substituted azaarenes under mild conditions without the need of prefunctionalization of 2-alkylazaarenes or using the specialized arylating agents.

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