Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jul;33(7):359-364.
doi: 10.1016/j.kjms.2017.04.003. Epub 2017 May 9.

Glutathione peroxidase 3 gene polymorphisms and the risk of sudden sensorineural hearing loss

Chen-Yu Chien  1 , Tzu-Yen Huang  2 , Shu-Yu Tai  3 , Ning-Chia Chang  4 , Hsun-Mo Wang  5 , Ling-Feng Wang  6 , Kuen-Yao Ho  1
Affiliations

Glutathione peroxidase 3 gene polymorphisms and the risk of sudden sensorineural hearing loss

Chen-Yu Chien et al. Kaohsiung J Med Sci. 2017 Jul.

Abstract

The glutathione peroxidase 3 gene (GPX3) is reported to be a risk factor for arterial ischaemic stroke and cerebral venous thrombosis. GPX3 may be one of the aetiologies of sudden sensorineural hearing loss (SSNHL), which might be attributed to the genetic effect of GPX3 by influence reactive oxygen species (ROS). Unbalanced ROS have been associated with susceptibility to SSNHL. Therefore, we conducted a case-control study with 416 SSNHL cases and 255 controls. Five single nucleotide polymorphisms (SNPs) were selected. The genotypes were determined using TaqMan genotyping assays. Each SNP was tested using the Hardy-Weinberg equilibrium (HWE), and the genetic effects were evaluated using three inheritance models. All five SNPs were in HWE. As the result, the AG genotype of rs3805435 had an adjusted odds ratio (OR) of 0.54 (95% confidence interval = 0.37-0.79, p = 0.001) compared with the AA genotype in the SSNHL cases. The GG and AG genotypes of the SNP rs3805435 were associated with SSNHL under the dominant model (p = 0.002, OR = 0.58). In conclusion, these results suggest that GPX3 polymorphisms influence susceptibility to SSNHL in southern Taiwan.

Keywords: Glutathione peroxidase 3; Polymorphism; Sudden sensorineural hearing loss.

PubMed Disclaimer

References

    1. Byl F.M. Jr.. Sudden hearing loss: eight years' experience and suggested prognostic table. Laryngoscope. 1984; 94: 647–661. - PubMed
    1. Wu C.S., Lin H.C., Chao P.Z.. Sudden sensorineural hearing loss: evidence from Taiwan. Audiol Neurootol. 2006; 11: 151–156. - PubMed
    1. Schreiber B.E., Agrup C., Haskard D.O., Luxon L.M.. Sudden sensorineural hearing loss. Lancet. 2010; 375: 1203–1211. - PubMed
    1. Chien C.Y., Chang N.C., Tai S.Y., Wang L.F., Wu M.T., Ho K.Y.. Heat shock protein 70 gene polymorphisms in sudden sensorineural hearing loss. Audiol Neurootol. 2012; 17: 381–385. - PubMed
    1. Shu J., Yin S., Tan A.Z., He M.. Association between the methylenetetrahydrofolate reductase gene C677T polymorphism and sudden sensorineural hearing loss: a meta‐analysis. Eur Arch Otorhinolaryngol. 2014; 272: 2267–2274. - PubMed

Substances