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. 2017 Jul;54(8):2260-2269.
doi: 10.1007/s13197-017-2663-z. Epub 2017 Jun 14.

Effects of marine collagen peptides on glucose metabolism and insulin resistance in type 2 diabetic rats

CuiFeng Zhu  1   2   3 , Wei Zhang  2 , Bo Mu  4 , Fan Zhang  5 , NanNan Lai  6 , JianXin Zhou  2 , AiMin Xu  3 , JianGuo Liu  1 , Yong Li  7
Affiliations

Effects of marine collagen peptides on glucose metabolism and insulin resistance in type 2 diabetic rats

CuiFeng Zhu et al. J Food Sci Technol. 2017 Jul.

Abstract

The present study was conducted to investigate the effects of marine collagen peptides (MCPs) on glucose metabolism and insulin resistance using a rat model of type 2 diabetes mellitus (T2DM). Forty T2DM obese Wistar rats were randomly assigned to receive varying doses of MCPs or a vehicle control for 4 weeks. Blood glucose and insulin levels, as well as oxidative stress and inflammation were measured. The expression of glucose transporter type 4 (GLUT4) in skeletal muscles and peroxisome proliferator-activated receptor-α (PPAR-α) in livers of T2DM rats was also measured. It was found that in the group of 9.0 g/kg/day MCPs significantly improved glucose, insulin, and homeostatic model assessment-insulin resistance, and increased the insulin sensitivity index (ISI). In addition, the groups of 4.5 and 2.25 g/kg/day MCPs significantly improved liver steatosis. It was also found that MCPs decreased expression of oxidative stress biomarkers and inflammatory cytokines and adipocytokines in T2DM rats. In conclusion, medium and high doses of MCPs (≥4.5 g/kg/day) improved glucose metabolism and insulin sensitivity in T2DM rats. These beneficial effects of MCPs may be mediated by decreasing oxidative stress and inflammation and by up-regulating GLUT4, and PPAR-α activity.

Keywords: Adipocytokine; Inflammatory cytokines; Insulin resistance; Marine collagen peptide; Oxidative stress.

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Conflict of interest statement

The authors have no potential conflicts of interest relevant to this article.

Figures

Fig. 1
Fig. 1
Effects of MCPs on the expression of oxidative stress biomarkers in type 2 diabetic rats. Normal rats received a vehicle control and obese Wistar rats with type 2 diabetes received a vehicle control or different doses of MCPs. Each group included 10 rats. After 4 weeks, blood levels of SOD, GSH, NO, and MDA (A), and TNF-α, IFN-γ, and CRP (B) were measured
Fig. 2
Fig. 2
MCPs regulate expression of inflammation biomarkers in type 2 diabetic rats. Normal rats received a vehicle control and obese Wistar rats with type 2 diabetes received a vehicle control or different doses of MCPs. Each group included 10 rats. After 4 weeks, blood levels of adiponectin (a), leptin (b) and resistin (c) were measured
Fig. 3
Fig. 3
MCPs up-regulate GLUT4 expression in the skeletal muscle of type 2 diabetic rats. Normal rats received a vehicle control and obese Wistar rats with type 2 diabetes received a vehicle control or different doses of MCPs. Each group included 10 rats. After 4 weeks, rats were sacrificed, and skeletal muscle was observed using immunohistochemistry. The cumulative optical density value (IOD) was used to evaluate the signal of GLUT4 in the skeletal muscle, with a higher IOD value indicating a stronger immunohistochemical signal
Fig. 4
Fig. 4
MCPs improve liver steatosis and up-regulate PPAR-α expression in livers from type 2 diabetic rats. Normal rats received a vehicle control and obese Wistar rats with type 2 diabetes received a vehicle control or different doses of MCPs. Each group included 10 rats. After 4 weeks, rats were sacrificed, and livers were stained by H&E and immnuohistochemistry. PPAR-α positive cells were counted randomly in ten fields from each sample
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