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. 2016 May;2(5):217-218.
doi: 10.1016/j.trecan.2016.04.003. Epub 2016 Apr 28.

A Molecular Take on Malignant Rhabdoid Tumors

Ming Tang  1 , Roel G W Verhaak  2
Affiliations

A Molecular Take on Malignant Rhabdoid Tumors

Ming Tang et al. Trends Cancer. 2016 May.

Abstract

The molecular basis for the clinical heterogeneity observed in patients with malignant rhabdoid tumors is unknown. Recently, two reports revealed molecular intertumor heterogeneity in teratoid/rhabdoid tumors (ATRTs) and extra-cranial MRTs (ecMRTs) using genomic, transcriptomic, and epigenomic profiling. Distinct molecular subgroups were identified and new therapeutic targets were revealed.

Keywords: malignant rhabdoid tumors; molecular analysis; pediatric cancer; sequencing.

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