doi: 10.1253/jcj.50.238.
Classification of beta-blocking agents by their inhibitory effects on phospholipase activity
- PMID: 2874241
- DOI: 10.1253/jcj.50.238
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Classification of beta-blocking agents by their inhibitory effects on phospholipase activity
Jpn Circ J.
1986 Mar.
Abstract
The inhibitory effects of beta-blocking agents against the action of phospholipase (PLase) were investigated. Using micelles of dimyristoyl (-)-alpha-phosphatidylcholine (DMPC) as a substrate, myristic acid (MA) released from DMPC by PLase A2 was determined by gas chromatography. Beta-Blocking agents were divided into 4 groups depending on their inhibitory effects on PLase. Their inhibitory effects on PLase could be due to their displacing ability with Ca++ on membrane phospholipids, since Ca++ is an essential factor for the activation of PLase.
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