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. 1986 Mar;50(3):238-41.
doi: 10.1253/jcj.50.238.

Classification of beta-blocking agents by their inhibitory effects on phospholipase activity

S Nagai, S Sugiyama, T Ozawa

Classification of beta-blocking agents by their inhibitory effects on phospholipase activity

S Nagai et al. Jpn Circ J. 1986 Mar.

Abstract

The inhibitory effects of beta-blocking agents against the action of phospholipase (PLase) were investigated. Using micelles of dimyristoyl (-)-alpha-phosphatidylcholine (DMPC) as a substrate, myristic acid (MA) released from DMPC by PLase A2 was determined by gas chromatography. Beta-Blocking agents were divided into 4 groups depending on their inhibitory effects on PLase. Their inhibitory effects on PLase could be due to their displacing ability with Ca++ on membrane phospholipids, since Ca++ is an essential factor for the activation of PLase.

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