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Comment
. 2017 Jul 24;42(2):112-114.
doi: 10.1016/j.devcel.2017.07.004.

Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer

Ana P Gomes  1 , Tanya Schild  1 , John Blenis  2
Affiliations
Comment

Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer

Ana P Gomes et al. Dev Cell. .

Abstract

The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) is a major nutrient sensor and regulator of cellular metabolic flux. Reporting recently in Nature, Zabala-Letona et al. (2017) show that mTORC1 regulates an additional branch of metabolism in the cell-polyamine synthesis-that is important for prostate cancer tumorigenicity.

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Figures

Figure 1
Figure 1. mTORC1 as the Master Regulator of Metabolic Reprogramming
The mTORC1 signaling network senses intracellular (e.g., energy) and extracellular (e.g., growth factors, nutrients) cues and induces changes in intermediary metabolism to meet cellular needs and maintain cellular homeostasis. Activation of mTORC1 represses catabolic processes, induces polyamine synthesis, and promotes a multitude of anabolic processes, thus producing the major components necessary to sustain cell growth and proliferation.
See this image and copyright information in PMC

Comment on

  • mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.
    Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita J, Muñoz J, Falcón-Pérez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A. Zabala-Letona A, et al. Nature. 2017 Jul 6;547(7661):109-113. doi: 10.1038/nature22964. Epub 2017 Jun 28. Nature. 2017. PMID: 28658205 Free PMC article.

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