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. 2017 May;15(5):273-278.

The effects of multi mineral-vitamin D and vitamins (C+E) supplementation in the prevention of preeclampsia: An RCT

Milad Azami  1 , Tayebe Azadi  2 , Sepidezahra Farhang  3 , Shoobo Rahmati  1 , Khadijeh Pourtaghi  2
Affiliations
Free PMC article

The effects of multi mineral-vitamin D and vitamins (C+E) supplementation in the prevention of preeclampsia: An RCT

Milad Azami et al. Int J Reprod Biomed. 2017 May.
Free PMC article

Abstract

Background: Several studies have reported the uncertain role of multi-minerals and vitamins in the prevention of preeclampsia.

Objective: The present study aims to investigate the effect of multimineral-vitamin D supplements (calcium, magnesium, zinc and Vitamin D) and vitamins (C+ E) in the prevention of preeclampsia.

Materials and methods: In this randomized clinical trial, 90 pregnant women were divided into three groups: group A received Ferrous sulfate (1 tablet/day) + one tablet of Claci-care multimineral-vitamin D containing 800mg calcium, 200mg magnesium, 8mg zinc and 400 IU Vitamin D3 per day; group B received Ferrous sulfate (1 tablet/day) + 250 mg vitamin C + 55 mg vitamin E; and the controls received only one Ferrous sulfate tablet daily.

Results: The incidence of preeclampsia in group A was significantly lower than the control group (p=0.03), while there was no significant difference between group B and controls (p=0.50), as well as groups A and B (p=0.063). The incidence of neonatal complications in the group A was significantly lower than the control group (p=0.01), while there was no significant difference between group B and control (p=0.48).

Conclusion: According to the results, calcium, magnesium, and zinc supplements have a significant effect on the prevention of preeclampsia. In addition, prescription of multimineral-vitamin D during pregnancy can be a low-cost and affordable way to reduce the incidence of preeclampsia in women who are at high risk of preeclampsia.

Keywords: Calcium; Magnesium; Preeclampsia; Prevention; Vitamin C; Vitamin D; Vitamin E; Zinc.

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Conflict of interest statement

Authors have no conflict of interest.

Figures

Figure 1
Figure 1
Follow-up Method Based on CONSORT 2010 Flow Diagram
Figure 2
Figure 2
Comparison of the effect of multimineral-vitamin D (Zn, Mg, Ca and vitamin D3) and vitamins (C and E) supplementations in the prevention of preeclampsia
Figure 3
Figure 3
Comparison of the effect of multimineral-vitamin D (Zn, Mg, Ca and vitamin D3) and vitamins (C and E) supplementations in the neonatal complications
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