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Review
. 2017 Sep;11(5):372-393.
doi: 10.1111/irv.12470.

The hidden burden of influenza: A review of the extra-pulmonary complications of influenza infection

Subhashini A Sellers  1 , Robert S Hagan  1 , Frederick G Hayden  2 , William A Fischer 2nd  1
Affiliations
Review

The hidden burden of influenza: A review of the extra-pulmonary complications of influenza infection

Subhashini A Sellers et al. Influenza Other Respir Viruses. 2017 Sep.

Abstract

Severe influenza infection represents a leading cause of global morbidity and mortality. Although influenza is primarily considered a viral infection that results in pathology limited to the respiratory system, clinical reports suggest that influenza infection is frequently associated with a number of clinical syndromes that involve organ systems outside the respiratory tract. A comprehensive MEDLINE literature review of articles pertaining to extra-pulmonary complications of influenza infection, using organ-specific search terms, yielded 218 articles including case reports, epidemiologic investigations, and autopsy studies that were reviewed to determine the clinical involvement of other organs. The most frequently described clinical entities were viral myocarditis and viral encephalitis. Recognition of these extra-pulmonary complications is critical to determining the true burden of influenza infection and initiating organ-specific supportive care.

Keywords: extra-pulmonary complications; influenza; respiratory virus; viral encephalitis; viral myocarditis.

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Figures

Figure 1
Figure 1
Results of search strategy
See this image and copyright information in PMC

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