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Review
. 2017 Jul 26;15(1):162.
doi: 10.1186/s12967-017-1263-z.

The European ME/CFS Biomarker Landscape project: an initiative of the European network EUROMENE

Carmen Scheibenbogen  1 , Helma Freitag  2 , Julià Blanco  3   4 , Enrica Capelli  5   6 , Eliana Lacerda  7 , Jerome Authier  8 , Mira Meeus  9   10   11 , Jesus Castro Marrero  12 , Zaiga Nora-Krukle  13 , Elisa Oltra  14   15 , Elin Bolle Strand  16   17 , Evelina Shikova  18 , Slobodan Sekulic  19 , Modra Murovska  13
Affiliations
Review

The European ME/CFS Biomarker Landscape project: an initiative of the European network EUROMENE

Carmen Scheibenbogen et al. J Transl Med. .

Abstract

Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a common and severe disease with a considerable social and economic impact. So far, the etiology is not known, and neither a diagnostic marker nor licensed treatments are available yet. The EUROMENE network of European researchers and clinicians aims to promote cooperation and advance research on ME/CFS. To improve diagnosis and facilitate the analysis of clinical trials surrogate markers are urgently needed. As a first step for developing such biomarkers for clinical use a database of active biomarker research in Europe was established called the ME/CFS EUROMENE Biomarker Landscape project and the results are presented in this review. Further we suggest strategies to improve biomarker development and encourage researchers to take these into consideration for designing and reporting biomarker studies.

Keywords: Autoantibodies; Autoimmunity; B cell; Biomarker; Cytokines; Diagnostic; European network; Landscape project; ME/CFS; Viral.

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Figures

Fig. 1
Fig. 1
Biomarker studies were categorized as metabolic, immunological, neurological or infection-associated. The data was visualized as total numbers of studies (size of cake) per category (piece of cake) from each country, and the numbers of active biomarker research groups is indicated in the countries. EUROMENE countries are indicated by grey (dark grey countries with published studies, light grey those without studies) and non-EUROMENE by white
See this image and copyright information in PMC

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