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Review
. 2017 Sep;8(5):555-560.
doi: 10.1016/j.jare.2017.05.001. Epub 2017 May 5.

Asymptomatic hyperuricemia and chronic kidney disease: Narrative review of a treatment controversial

Theodoros Eleftheriadis  1 , Spyridon Golphinopoulos  1 , Georgios Pissas  1 , Ioannis Stefanidis  1
Affiliations
Review

Asymptomatic hyperuricemia and chronic kidney disease: Narrative review of a treatment controversial

Theodoros Eleftheriadis et al. J Adv Res. 2017 Sep.

Abstract

Today there is plausible evidence both on experimental and epidemiological basis, that hyperuricemia represents a risk factor for the development and progression of chronic kidney disease (CKD). Nevertheless, the role of serum uric acid lowering treatment in CKD is still a matter of serious controversy. Review of randomised controlled trials, suggests that there may be an improvement of renal function with allopurinol treatment in CKD stage 3-5. However, these studies have included a relatively limited number of participants and provide insufficient information on adverse events and on the incidence of the end stage renal disease. Therefore, before adequately powered randomised, placebo-controlled trials are completed we cannot recommend treating asymptomatic hyperuricemia in patients with CKD.

Keywords: Chronic kidney disease; Hyperuricemia; Urate lowering treatment; Uric acid.

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