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Editorial
. 2017;16(17):1562-1563.
doi: 10.1080/15384101.2017.1355179. Epub 2017 Jul 27.

The nucleolus: A new home for the PIDDosome

Lisa Bouchier-Hayes  1   2 , Samuel Sidi  3   4
Affiliations
Editorial

The nucleolus: A new home for the PIDDosome

Lisa Bouchier-Hayes et al. Cell Cycle. 2017.
No abstract available

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Figures

Figure 1.
Figure 1.
Model of differential caspase-2 activation platform assembly in the cytosol and nucleolus. DNA damage leads to the assembly of 2 distinct caspase-2 activation platforms (represented by yellow circles): one in the cytosol and one in the nucleolus. The nucleolar complex comprises NPM1 (nucleophosmin), PIDD (p53-inducible protein with a death domain) and RAIDD (RIP-associated Ich-1/CED homologous protein with death domain) while the cytoplasmic complex only requires RAIDD. Other stimuli (e.g. cytoskeletal damage) only engage the cytosolic platform.
See this image and copyright information in PMC

Comment on

References

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