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. 2017 Jul 27;59(1):51.
doi: 10.1186/s13028-017-0318-8.

Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle

Suhee Kim  1 , Do-Hyeon Yu  2 , Jeong-Byoung Chae  3 , Kyoung-Seong Choi  4 , Hyeon-Cheol Kim  5 , Bae-Keun Park  6 , Joon-Seok Chae  3 , Jinho Park  7
Affiliations

Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle

Suhee Kim et al. Acta Vet Scand. .

Abstract

Serious disease outbreaks in cattle caused by Theileria orientalis have emerged in the Asia-Pacific region. Genetic variables of the major piroplasm surface protein (MPSP) expressed on the surface of the piroplasm inside T. orientalis-infected erythrocytes are considered to be associated with variation in the pathogenicity of T. orientalis. Our study describes the clinically relevant MPSP types associated with anemia in Theileria-infected cattle. These results revealed that MPSP expression plays an important role in hematological alterations in Theileria-infected cattle, and that MPSP type 1 is strongly associated with bovine anemia, which can be a potential target for the prevention of bovine theileriosis.

Keywords: Anemia; MPSP type 1; Major piroplasm surface protein; Theileria orientalis.

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Figures

Fig. 1
Fig. 1
Development of anemia according to major piroplasm surface protein (MPSP) genotypes in Theileria-infected cattle. Comparison of red blood cell count (RBC), hemoglobin (Hb), and hematocrit (HCT) values among MPSP types (a) and the presence of anemia in each MPSP type (b). Colored bars indicated the level of anemia. Blue no anemia; orange mild anemia and red severe anemia. Number of animals: MPSP-negative (n = 34); types 1 (n = 20), 2 (n = 32), 3 (n = 2) and 7 (n = 2). *P < 0.05 and **P < 0.001
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