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. 2017 Aug 7;12(8):1311-1320.
doi: 10.2215/CJN.10130916. Epub 2017 Jul 27.

Outcomes of Deceased Donor Kidney Offers to Patients at the Top of the Waiting List

Anne M Huml  1   2   3 , Jeffrey M Albert  4 , J Daryl Thornton  1   5 , Ashwini R Sehgal  1   4   2
Affiliations

Outcomes of Deceased Donor Kidney Offers to Patients at the Top of the Waiting List

Anne M Huml et al. Clin J Am Soc Nephrol. .

Abstract

Background and objectives: Transplant centers may accept or refuse deceased-donor kidneys that are offered to their patients at the top of the waiting list. We sought to determine the outcomes of deceased-donor kidney offers and their association with characteristics of waitlisted patients and organ donors.

Design, setting, participants, & measurements: We examined all 7 million deceased-donor adult kidney offers in the United States from 2007 to 2012 that led to eventual transplantation. Data were obtained from the national organ allocation system through the United Network of Organ Sharing. The study cohort consisted of 178,625 patients waitlisted for a deceased-donor kidney transplant and 31,230 deceased donors. We evaluated offers made to waitlisted patients and their outcomes (transplantation or specific reason for refusal).

Results: Deceased-donor kidneys were offered a median of seven times before being accepted for transplantation. The most common reasons for refusal of an offer were donor-related factors, e.g., age or organ quality (3.2 million offers, 45.0%), and transplant center bypass, e.g., minimal acceptance criteria not met (3.2 million offers, 44.0%). After adjustment for characteristics of waitlisted patients, organ donors, and transplant centers, male (odds ratio [OR], 0.93; 95% confidence interval [95% CI], 0.91 to 0.95) and Hispanic (OR, 0.96; 95% CI, 0.93 to 0.99) waitlisted patients were less likely to have an offer accepted than female and white patients, respectively. The likelihood of offer acceptance varied greatly across transplant centers (interquartile ratio, 2.28).

Conclusions: Transplant centers frequently refuse deceased-donor kidneys. Such refusals differ by patient and donor characteristics, may contribute to disparities in access to transplantation, and vary greatly across transplant centers.

Podcast: This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2017_07_27_Huml.mp3.

Keywords: deceased donor offer; kidney transplantation; waiting list.

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Figures

Figure 1.
Figure 1.
Outcomes of offers varied greatly across transplant centers. Distribution of actual/expected outcomes (standardized ratios) of offers across 221 transplant centers. Boxes show the median as the line across the middle and the 25th and 75th percentiles as ends. Lines represent the 10th and 90th percentiles. The interquartile ratio (ratio of 75th to 25th percentile) is above each box.
See this image and copyright information in PMC

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