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. 2017 Jul 15;8(7):374-380.
doi: 10.4239/wjd.v8.i7.374.

Effect of bariatric surgery on adiposity and metabolic profiles: A prospective cohort study in Middle-Eastern patients

Mohsen Mazidi  1 , Peyman Rezaie  1 , Ali Jangjoo  1 , Alireza Tavassoli  1 , Mohammad Taghi Rajabi  1 , Andre Pascal Kengne  1 , Mohsen Nematy  1
Affiliations

Effect of bariatric surgery on adiposity and metabolic profiles: A prospective cohort study in Middle-Eastern patients

Mohsen Mazidi et al. World J Diabetes. .

Abstract

Aim: To investigate changes in adiposity and cardio-metabolic risk profile following Roux-en-Y gastric bypass in patients of Middle Eastern ethnicity with severe obesity.

Methods: This prospective cohort study involved 92 patients who met the indications of bariatric surgery. Post-procedure markers of obesity and cardiometabolic profile were monitored regularly for a year.

Results: Mean body mass index decreased by 29.5% from 41.9 to 29.5 kg/m2 between baseline and 12-mo follow-up, while mean fat mass decreased by 45.9% from 64.2 kg to 34.7 kg. An improvement was also observed in the gluco-metabolic profile with both fasting glucose and HbA1c substantially decreasing (P < 0.001).

Conclusion: The present study shows the short to medium term (1 year) health benefits of bariatric surgery for patients of Middle Eastern ethnicity.

Keywords: Anthropometric indices; Bariatric surgery; Cardiometabolic risk; Metabolic profile.

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Conflict of interest statement

Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.

Figures

Figure 1
Figure 1
Increased concentration of bile acids caused to activation of farnesoid X receptor A and G protein-coupled bile acid receptor, these two receptors have adverse impact on different tissues. Activation of farnesoid X receptor A (FXRA) and G protein-coupled bile acid receptor (TGR5) can stimulate the secretion of glucagon-like peptide I and II (GLP), and GLP have positive effect on pancreas.
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References

    1. Fallahi-Shahabad S, Mazidi M, Tavasoli A, Rezaie P, Rohani F, Habibzadeh S, Darchini-Maragheh E, Sefidi ZS, Safarian M, Mobarhan MG, et al. Metabolic improvement of morbid obese patients following Roux-en-Y gastric bypass surgery: A prospective study in Mashhad, Iran. Indian J Gastroenterol. 2016;35:195–200. - PubMed
    1. Bastien M, Poirier P, Lemieux I, Després JP. Overview of epidemiology and contribution of obesity to cardiovascular disease. Prog Cardiovasc Dis. 2015;56:369–381. - PubMed
    1. Feingold KR, Grunfeld C. Obesity and Dyslipidemia. In: De Groot LJ, Chrousos G, Dungan K, Feingold KR, Grossman A, et al., editors. SourceEndotext [Internet] South Dartmouth (MA): MDText.com, Inc; 2000.
    1. Hall ME, do Carmo JM, da Silva AA, Juncos LA, Wang Z, Hall JE. Obesity, hypertension, and chronic kidney disease. Int J Nephrol Renovasc Dis. 2014;7:75–88. - PMC - PubMed
    1. Leonetti F, Capoccia D, Coccia F, Casella G, Baglio G, Paradiso F, Abbatini F, Iossa A, Soricelli E, Basso N. Obesity, type 2 diabetes mellitus, and other comorbidities: a prospective cohort study of laparoscopic sleeve gastrectomy vs medical treatment. Arch Surg. 2012;147:694–700. - PubMed