Recent advances in understanding eosinophil biology

doi:10.12688/f1000research.11133.1

Review

. 2017 Jul 7:6:1084.

doi: 10.12688/f1000research.11133.1. eCollection 2017.

Recent advances in understanding eosinophil biology

Amy Klion¹

Affiliations

Affiliation

¹ Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

PMID: 28751971
PMCID: PMC5506535
DOI: 10.12688/f1000research.11133.1

Review

Recent advances in understanding eosinophil biology

Amy Klion. F1000Res. 2017.

. 2017 Jul 7:6:1084.

doi: 10.12688/f1000research.11133.1. eCollection 2017.

Author

Amy Klion¹

Affiliation

¹ Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

PMID: 28751971
PMCID: PMC5506535
DOI: 10.12688/f1000research.11133.1

Abstract

With the advent of novel therapies targeting eosinophils, there has been renewed interest in understanding the basic biology of this unique cell. In this context, murine models and human studies have continued to highlight the role of the eosinophil in homeostatic functions and immunoregulation. This review will focus on recent advances in our understanding of eosinophil biology that are likely to have important consequences on the development and consequences of eosinophil-targeted therapies. Given the breadth of the topic, the discussion will be limited to three areas of interest: the eosinophil life cycle, eosinophil heterogeneity, and mechanisms of cell-cell communication.

Keywords: cell-cell communication; eosinophils; heterogeneity; life cycle.

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Conflict of interest statement

Competing interests: The author declares that she has no competing interests.No competing interests were disclosed.No competing interests were disclosed.

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References

1. Balla KM, Lugo-Villarino G, Spitsbergen JM, et al. : Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants. Blood. 2010;116(19):3944–54. 10.1182/blood-2010-03-267419 - DOI - PMC - PubMed
1. Wen T, Rothenberg ME: The Regulatory Function of Eosinophils. Microbiol Spectr. 2016;4(5). 10.1128/microbiolspec.MCHD-0020-2015 - DOI - PMC - PubMed
1. Rosenberg HF, Dyer KD, Foster PS: Eosinophils: changing perspectives in health and disease. Nat Rev Immunol. 2013;13(1):9–22. 10.1038/nri3341 - DOI - PMC - PubMed
1. Yu C, Cantor AB, Yang H, et al. : Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J Exp Med. 2002;195(11):1387–95. 10.1084/jem.20020656 - DOI - PMC - PubMed
1. Lee JJ, Dimina D, Macias MP, et al. : Defining a link with asthma in mice congenitally deficient in eosinophils. Science. 2004;305(5691):1773–6. 10.1126/science.1099472 - DOI - PubMed

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[1] Balla KM, Lugo-Villarino G, Spitsbergen JM, et al. : Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants. Blood. 2010;116(19):3944–54. 10.1182/blood-2010-03-267419 - DOI - PMC - PubMed

[2] Balla KM, Lugo-Villarino G, Spitsbergen JM, et al. : Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants. Blood. 2010;116(19):3944–54. 10.1182/blood-2010-03-267419 - DOI - PMC - PubMed

[3] Wen T, Rothenberg ME: The Regulatory Function of Eosinophils. Microbiol Spectr. 2016;4(5). 10.1128/microbiolspec.MCHD-0020-2015 - DOI - PMC - PubMed

[4] Wen T, Rothenberg ME: The Regulatory Function of Eosinophils. Microbiol Spectr. 2016;4(5). 10.1128/microbiolspec.MCHD-0020-2015 - DOI - PMC - PubMed

[5] Rosenberg HF, Dyer KD, Foster PS: Eosinophils: changing perspectives in health and disease. Nat Rev Immunol. 2013;13(1):9–22. 10.1038/nri3341 - DOI - PMC - PubMed

[6] Rosenberg HF, Dyer KD, Foster PS: Eosinophils: changing perspectives in health and disease. Nat Rev Immunol. 2013;13(1):9–22. 10.1038/nri3341 - DOI - PMC - PubMed

[7] Yu C, Cantor AB, Yang H, et al. : Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J Exp Med. 2002;195(11):1387–95. 10.1084/jem.20020656 - DOI - PMC - PubMed

[8] Yu C, Cantor AB, Yang H, et al. : Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J Exp Med. 2002;195(11):1387–95. 10.1084/jem.20020656 - DOI - PMC - PubMed

[9] Lee JJ, Dimina D, Macias MP, et al. : Defining a link with asthma in mice congenitally deficient in eosinophils. Science. 2004;305(5691):1773–6. 10.1126/science.1099472 - DOI - PubMed

[10] Lee JJ, Dimina D, Macias MP, et al. : Defining a link with asthma in mice congenitally deficient in eosinophils. Science. 2004;305(5691):1773–6. 10.1126/science.1099472 - DOI - PubMed

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Recent advances in understanding eosinophil biology

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Recent advances in understanding eosinophil biology

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Abstract

Conflict of interest statement

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