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Review
. 2017 Jul 11:6:1095.
doi: 10.12688/f1000research.11546.1. eCollection 2017.

Chronic urticaria: a focus on pathogenesis

Riccardo Asero  1 , Alberto Tedeschi  2 , Angelo Valerio Marzano  3 , Massimo Cugno  4
Affiliations
Review

Chronic urticaria: a focus on pathogenesis

Riccardo Asero et al. F1000Res. .

Abstract

Chronic urticaria is a spontaneous or inducible group of diseases characterized by the occurrence of wheals (and, in about half of cases, angioedema) for more than 6 weeks. These are rather frequent conditions that may severely affect patients' quality of life and sometimes represent a challenge for doctors as well. The causes of chronic urticaria are still poorly defined, although there is growing evidence that different biologic systems including immunity, inflammation, and coagulation may take part in the pathomechanism eventually leading to mast cell and basophil degranulation and hence to wheal formation. This review will discuss the main findings that are (slowly) shedding light on the pathogenesis of this disorder.

Keywords: Chronic Uritcaria; Omalizumab; autologous serum skin test; wheals.

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Conflict of interest statement

Competing interests: The authors declare that they have no competing interests.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

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